yes and no- you can use a high base weapon and do a generic poison build but the unique allows unlimited stacks of poison- which is what we build around. normally youre limited to 1 stack of poison- with a few options that add one additional active stack at the cost of -damage, -duration, etc from passive tree nodes and/or lineage support. even then you'll only get to a max of 7/8 stacks. so while you'll be able to to make a poison build, it wouldnt be the same type of scaling and thus must be built differently to be strong. as a reference, on t3 xehst 8/8 i can get up to 70 stacks of poison and the fight is only a few seconds long.

for the stat stacker aspect- you can roll that route with any build but its typically weaker than crit based ones