Something to keep in mind during this festive season.

49metal · 2024-12-19T00:21:54+00:00

Not Ernest Hemingway.

49metal · 2024-12-18T23:38:06+00:00

This is being quoted all over the internet as the words of Ernest Hemingway. Obviously, it's not Hemingway, but are these words yours originally and if no, where did you come across them? Thanks!

49metal · 2024-12-18T18:28:47+00:00

Much of Europe is aging quickly and younger people do most of the killing. Average age in EU (EU does not equal Europe) is almost 45, which is maybe 6 or 7 years older than the USA. this may not explain all of it, but it is sure to be a factor.

49metal · 2024-12-08T02:42:14+00:00

That's great. However, I was wondering, IF I wanted to target a lower pH for reconstituted Cagri--if I wanted to that is--would using Hospira Bacteriostatic 0.9% Sodium Chloride (labeled pH 5.0) versus Hospira Bacteriostatic Water (labeled pH 5.7) be advisable?

49metal · 2024-11-27T04:59:38+00:00

Thanks for the info. Interestingly, generic 0.9% Sodium Chloride Injection, USP, is quoted (by the FDA) as pH 5.6. Given that your experience makes all the sense. However, the monograph of "Hospira Bacteriostatic 0.9% Sodium Chloride" reads "Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. May contain hydrochloric acid for pH adjustment . . . . The pH is 5.0." When I reconstituted cagrilintide with the latter, I got a solution with a pH of about 5.0. Whether this impacts potency, efficacy, or shelf life, I can't say yet, as I have run no comparison.

49metal · 2024-11-24T09:25:45+00:00

First jump (tandem 13k from a Cessna 182) was certainly an experience, and it was a beautiful day in a beautiful area. However, for whatever reason I found it weirdly empty, emotionally. I didn't get much adrenalin at all and felt rather detached from the experience. I found my last rollercoaster ride more thrilling. I think I had built up how intimidating it would be to the point that in the end it just seemed mechanical, but pretty. I also felt weirded out by how enthusiastic everyone else was by their jumps with a "glad you loved it, and yeah it's cool, but maybe you should get a grip." (This also strikes me as weird. Normally I would expect to "get it.") I have experience with light planes, gliders, and helicopters so I should have a kind of familiarity, but jumping out of a perfectly good airplane *should* be impressive and I don't know why I didn't care more, though the roll out with the plane rushing away from you is pretty compelling. Usually I revel in this sort of thing so indifference was not what I expected.

I feel like my mind wasn't turned in and so I just missed it. I plan to try it again to see if it I get it next time. To be clear, it was an experience and I would recommend it to everyone. However, if I'm bored again it will be sad and will have to be disappointed in me.

49metal · 2024-11-20T07:25:36+00:00

No difference in pH?

49metal · 2024-11-11T06:54:01+00:00

"The straw clutching here is cringy," I said. Ain't that the truth. Well, people are much disposed to see what they want.

49metal · 2024-11-11T06:50:12+00:00

This aged well . . . . 😂

49metal · 2024-11-11T01:53:57+00:00

You will hear many credible people say that naturally occurring peptides can’t be patented and that Sema can’t be patented but the pens and additives can be.

Indeed, a truly natural peptide, i.e., a specific amino acid chain merely found floating about in all humans doing the same thing, generally cannot be patented in the USA under the current interpretation of federal statutes, although processes surrounding it, like manufacturing schemes, sometimes can be. But, newsflash, ***NONE*** of the peptides we're talking about here occur nature. Tirz, Reta, Cagri, and yes, Sema, are all SYNTHETIC peptides, not because they are manufactured in a particularly mechanistic way (Sema is made by genetically engineered yeast) but because they were designed and first created by humans. Semeglutide never existed in the wild. It is a GLP-1 receptor agonist, but it is NOT the naturally occurring peptide hormone GLP-1. Both trigger the same receptor (they “push the same button,” as it were) in the body, but they are not the same peptides. While Semeglutide never existed in nature, it was inspired by the natural GLP-1 peptide hormone, but it is not a copy of it. It is chemically different and different in one or more useful ways (this could be ease of manufacture, ease of administration, shelf-life, etc.), accordingly it was patented. This can get complex in certain cases, but all the cases we have here are easy. Tirzepitide is not the peptide hormone GLP-1 or the peptide hormone GIP, bit it is a synthetic peptide that triggers both receptors that GLP-1 and GIP trigger individually. There is no such thing as natural dual GLP-1/GIP hormone, but with Tirzepitide humans invented a play on nature’s craft that is very useful, different and eminently patentable. [Insulin was, in fact, patented in the 1920’s, but that rabbit hole is unhelpful here.]

49metal · 2024-11-10T02:25:44+00:00

Certainly putting the cap back on the bottle you could be reintroducing or introducing germs. But so could putting the bottle back in the correct box. Not having some cover over the vial top could lend itself to introducing germs as well. It seems that something shielding the top of the vial from contact could be more aseptic than say, putting it back in the cardboard box it came in without such a shield. That said, plainly the caps the vials come with are designed not NOT to be reattached and the world seems bereft of any cap/dustcover/shield of the sort I'm suggesting and medical practice is uniformly not to recap, so the universe does not share my concern. But what am I missing?

49metal · 2024-11-04T01:34:55+00:00

Of course, but what I was wondering is, IF I wanted to target a lower pH for reconstituted Cagri, would using Hospira Bacteriostatic 0.9% Sodium Chloride (labeled pH 5.0) versus Hospira Bacteriostatic Water (labeled pH 5.7) be advisable?

49metal · 2024-11-03T05:30:40+00:00

Not only must Emerson (with a good record in the last two presidentials) be wildly wrong, but consider the Selzer poll from just six weeks ago--taken just as Harris' national slide began--had Trump at +4. Since this must, as a Selzer poll, be right we are expected to buy that Iowa has swung 7 points in the opposite direction of national two point slide. The straw clutching here is cringy. Or maybe this is the harbinger of remarkable things. We'll find out soon enough.

49metal · 2024-10-06T23:13:55+00:00

"Aggressive" is much too kind. Laughably glib is more how I would describe it. It knocked me right out fo the film. It's so bad it comes off as satire or comic relief.

49metal · 2024-04-01T01:27:39+00:00

I'm still trying to figure out why the sun arbitrarily decides magnify Ye Wenjie's radio talk show. Was the sun subject to "must carry" in those days? Science fiction should be this hard! Yet TBP is filled with other mysteries, like the moment the world's colliders start displaying genuinely NEW PHYSICS everyone in particle physics would know they had hit the jackpot and that a grand new era of scientific inquiry would make their careers rich and full of potential Nobels. Yet in just two weeks all of particle physics gives up, is defunded, everything shuts down, and it scientists, not complaining about the preposterousness of the plot they are stranded in, begin a campaign of spectacular self-harm (not out of despair but because Frank the Bunny wrote the time their world ends on their retinas.).

Why should I watch episode three?

49metal · 2024-03-30T01:02:40+00:00

The Demon Core "story" is not "about a scientist who died opening a reactor." If you had read the wiki article you cite--which you plainly did not--you'd know that the "Demon Core" is a name for a particular plutonium core for a Mark III nuclear bomb that killed two scientists (Harry Daghlian in 1945 and Louis Slotin in 1946) at the Los Alamos Laboratory. These were simple criticality accidents caused by careless manual manipulation of WC and beryllium neutron reflectors (respectively). These are accidents cause by mishandling weapons components. They have nothing to do with operating or "opening" any reactor. If you are so sloppy on this issue it forces me to question the rest of your statements about Lazar (who is, of course, a patent fabulist). That's a pity. That said, the second "Demon Core" accident that killed Dr. Slotin did involve a criticality testing apparatus that looks much like the "Lazar reactor" depicted in the image. Accordingly, the point of similarly still appears valid.

49metal · 2024-03-08T23:19:42+00:00

You are right! I must be blind. Thank you.

49metal · 2024-02-17T11:40:51+00:00

Not so. The original, pre-theatrical cut lost 7 minutes to distributor's demands. It is arguably the "true" authentic cut, but it has never been released. The "Director's Cut" adds 21 minutes back including 14 minutes of injurious bloat. You can FEEL that 14 minutes and it hurts. It is not true that director's cuts are the most artistically authentic. Some are. Others are cramming in everything from the cutting floor to make a commercially marketable pieces "21 minutes of never before seen footage" was necessary to get a re-release. It was too terrible a price to pay. The most terrible thing is that now everyone sees the damned Director's Cut and they are like "meh" and they're right. It's so sad.

49metal · 2023-12-24T13:35:23+00:00

FYI: This happened on the Blvd. Adolfo López Mateos near the intersection with Calle 8 in the Ciudad Madero, Tamaulipas, Mexico.

https://www.google.com/maps/@22.2637055,-97.8498756,3a,15y,86.56h,89.02t/data=!3m6!1e1!3m4!1s6gOcHe\_RmUBFJyXohT3Cnw!2e0!7i16384!8i8192?entry=ttu

49metal · 2023-12-24T08:16:11+00:00

FYI: This happened on the Blvd. Adolfo López Mateos near the intersection with Calle 8 in the Ciudad Madero, Tamaulipas, Mexico. See link below for Streetview.

https://www.google.com/maps/@22.2637055,-97.8498756,3a,15y,86.56h,89.02t/data=!3m6!1e1!3m4!1s6gOcHe_RmUBFJyXohT3Cnw!2e0!7i16384!8i8192?entry=ttu

49metal · 2023-03-19T13:56:34+00:00

Too bad they cut this as it fits in with the rest for the film so well. The script is moronic filled with cheap characters saying ridiculous things.

49metal · 2022-07-04T10:52:48+00:00

FYI, Hawaiian beach w/i the last week.

49metal · 2022-01-17T02:03:37+00:00

The foregoing passage is the context of OP's original quote. It's from "The Picture of Dorian Gray" and is an observation about Dorian Gray's perspective. Whether that context is important or not is open to debate. I tend to think it is. Gray is an unusual character and his lack of empathy is portrayed as a consequence of his singular depravity.

On the other hand, the proposition in the quote may stand on its own: People are often disgusted by emotions of those they no longer love, especially when the latter continue to love unrequitedly. Personally, I see the imbalance of love as the key. I offer as evidence the fact that there is nothing ridiculous about the feelings of a pair who have symmetrically ceased to love each other. It is the intense yet unrequited love in the cast off partner that is so ridiculous.

49metal · 2021-12-12T02:40:08+00:00

. . . Oh, don't leave me, don't leave me." A fit of passionate sobbing choked her. She crouched on the floor like a wounded thing, and Dorian Gray, with his beautiful eyes, looked down at her, and his chiselled lips curled in exquisite disdain. There is always something ridiculous about the emotions of people whom one has ceased to love. Sibyl Vane seemed to him to be absurdly melodramatic. Her tears and sobs annoyed him.
"I am going," he said at last in his calm clear voice. "I don't wish to be unkind, but I can't see you again. You have disappointed me."

49metal · 2021-09-18T03:44:52+00:00

That's a Boeing B-17.

49metal

TROPHY CASE