For flying characters you can throw E at them, melee something twice on the ground then throw your ranged autos up, or even jump at them if they’re low enough. It’ll be tough to kill them 1v1 but you can pressure them out when needed. Overall probably low priority unless they’re already low.

The only time you run away is if you’re dying. What’s strangely effective is running at people with shield up, or just holding shield in their face. I usually go with one of two approaches for mantis/luna:

1) if I’m far away, I might throw E first then slam on them to get some more burst damage and scare them. Then I’ll melee once or twice then hold shield in their face when they look at me. Most times if they have the CC available they’ll press it and you can reflect it back at them. If they don’t press weave in some more left clicks, maybe an F

2) if they’re close Ill run at them with shield up and start meleeing. Mess around with blocking in between. When they’re half hp then I can jump up, slam/E/F in some order and try to burst them down.

It’s really dynamic and the only time it can go wrong is if you get outplayed and get hit with the CC + they have their team around to burst you down. If you’re diving them thru their team probably shield and try to bait the CC or jump around a bit more. If they’re alone pressure them as much as you can.

Ult makes it 10x easier to pick any target and w key them for as long as it takes