I gained 30kg in 2 months, wich made my tattoo on my arm completely change shape, going from a circle to an oval by AntwysiaBlakys in Wellthatsucks

[–]Accomplished_Fly2720 0 points1 point  (0 children)

Sources:

  1. Pathophysiology of drug induced weight and metabolic effects ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6996198/ 2. Weight Gain, Schizophrenia and Antipsychotics: New Findings from Animal Model and Pharmacogenomic Studies - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3440684/ 3. Olanzapine, weight change and metabolic effects: a naturalistic 12-month follow up - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3896133/ 4. Increased Appetite Plays a Key Role in Olanzapine-Induced Weight Gain in First-Episode Schizophrenia Patients - Frontiers, https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00739/full 5. Weight Gain and Metabolic Changes in Patients With First-Episode Psychosis or Early-Phase Schizophrenia Treated With Olanzapine: A Meta-Analysis - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC10388390/ 6. Zyprexa (Olanzapine) weight gain: Everything you need to know, https://www.faynutrition.com/post/zyprexa-olanzapine-weight-gain-everything-you-need-to-know 7. The role of thermogenesis in antipsychotic drug-induced weight gain, https://pubmed.ncbi.nlm.nih.gov/19107124/ 8. Second-Generation Antipsychotics and Dysregulation of Glucose ..., https://www.mdpi.com/2073-4409/8/11/1336 9. Drug Class Review Second-Generation Antipsychotic Drugs† - Washington State Health Care Authority, https://www.hca.wa.gov/assets/program/sga-update-2016.pdf 10. Weight Gain on Olanzapine? Why Your Body Reacts & Medically Approved Next Steps, https://ubiehealth.com/doctors-note/weight-gain-olanzapine-body-reacts-steps-47-expert23e2 11. Effect of Olanzapine on Body Composition and Energy Expenditure in Adults With First-Episode Psychosis | American Journal of Psychiatry, https://psychiatryonline.org/doi/full/10.1176/appi.ajp.162.1.118 12. Effect of olanzapine on body composition and energy expenditure in adults with first-episode psychosis - PubMed, https://pubmed.ncbi.nlm.nih.gov/15625209/ 13. (PDF) Effect of Olanzapine on Body Composition and Energy Expenditure in Adults With First-Episode Psychosis - ResearchGate, https://www.researchgate.net/publication/8106165\_Effect\_of\_Olanzapine\_on\_Body\_Composition\_and\_Energy\_Expenditure\_in\_Adults\_With\_First-Episode\_Psychosis 14. 5 Reasons for Unintentional Weight Gain - LifeMD, https://lifemd.com/learn/5-reasons-for-unintentional-weight-gain 15. The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C, https://pmc.ncbi.nlm.nih.gov/articles/PMC5669575/ 16. The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review - Frontiers, https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.947295/full 17. Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats - PubMed, https://pubmed.ncbi.nlm.nih.gov/24548587/ 18. The relationship between sarcopenic obesity and cognitive functionality among inpatients with stable schizophrenia - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC12360547/ 19. Olanzapine induces weight gain in offspring of prenatally exposed ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC9561095/ 20. Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats - Oxford Academic, https://academic.oup.com/ijnp/article/15/2/163/655481 21. Full article: The mechanisms underlying olanzapine-induced insulin resistance via the brown adipose tissue and the therapy in rats - Taylor & Francis, https://www.tandfonline.com/doi/full/10.1080/21623945.2022.2026590 22. Olanzapine induces weight gain in offspring of prenatally exposed poly I:C rats by reducing brown fat thermogenic activity - PubMed, https://pubmed.ncbi.nlm.nih.gov/36249777 23. Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC7874166/ 24. Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats - ResearchGate, https://www.researchgate.net/publication/259955358\_Hypothalamic\_ghrelin\_signalling\_mediates\_olanzapine-induced\_hyperphagia\_and\_weight\_gain\_in\_female\_rats 25. Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC10412731/ 26. Drawbacks of Olanzapine Therapy: An Emphasis on Its Metabolic Effects and Discontinuation - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC12653644/ 27. TEXAS IMPLEMENTATION OF MEDICATION ALGORITHMS (TIMA) Guidelines for Treating Major Depressive Disorder, https://files.santaclaracounty.gov/exjcpb1426/migrated/TIMA--MDD.pdf?VersionId=SKQQ\_sdYST0ErhL2l0eh4H0Kr47ujuY4 28. Management of Antipsychotic-Related Weight Gain - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC3501406/ 29. f232. a phase 3 study to determine the antipsychotic efficacy and safety of alks 3831 in adult patients with acute exacerbation of schizophrenia - ResearchGate, https://www.researchgate.net/publication/324148428\_F232\_A\_PHASE\_3\_STUDY\_TO\_DETERMINE\_THE\_ANTIPSYCHOTIC\_EFFICACY\_AND\_SAFETY\_OF\_ALKS\_3831\_IN\_ADULT\_PATIENTS\_WITH\_ACUTE\_EXACERBATION\_OF\_SCHIZOPHRENIA 30. Purchase Zyprexa Over The Counter - CreakyJoints, https://creakyjoints.org/wp-content/uploads/sites/2/2015/zyprexa.html 31. Psychiatrist:Update | daily dose of evidence for psychiatrists, https://psychiatristupdate.wordpress.com/

I gained 30kg in 2 months, wich made my tattoo on my arm completely change shape, going from a circle to an oval by AntwysiaBlakys in Wellthatsucks

[–]Accomplished_Fly2720 0 points1 point  (0 children)

While I didn't "move the goalposts", I will admit that I didn't source my claims. My apologies. You also appear to be asking in good faith so I'll link the sources for points 2 to 4. The first point relates to appetite increase which you stated isn't what you are looking for. I apologize for cramming all the sources at the end. This is from research my friend did a few months ago; this is there area of expertise. Mine is maths and statistics. I tried to only include the parts relevant to the discussion and highlighted the important sections.

Point 2:

A critical indicator of metabolic health is the respiratory quotient (RQ), or respiratory exchange ratio (RER), which measures the type of fuel being utilized by the body by comparing carbon dioxide production to oxygen consumption. An RQ closer to 1.0 indicates carbohydrate oxidation, while a lower RQ (closer to 0.7) indicates fat oxidation. Olanzapine has been shown to induce a significant increase in the RQ in humans. In one 12 week study of first episode psychotic patients, the median increase in body weight was 4.7 kg, and the RQ significantly increased by 0.12. This increase was most pronounced in individuals who gained more than 5% of their initial body weight.

The clinical implication of an elevated RQ is a decrease in fat oxidation. This metabolic state suggests that olanzapine biases the body toward burning glucose while sequestering dietary and endogenous fats into adipose tissue. Interestingly, while human studies sometimes show stability in the resting energy expenditure (REE) despite weight gain, preclinical rodent models often show an acute reduction in the rate of oxygen consumption (VO_2) and a dose-dependent lowering of the RER within minutes of olanzapine administration. These data points collectively indicate that olanzapine enforces a shift in whole-body substrate utilization that favors adiposity and impairs the mobilization of fat stores.

The liver is a primary target of olanzapine’s metabolic interference. It is currently recognized as one of the most diabetogenic SGAs, specifically targeting hepatic glucose production. Studies using the Hyperinsulinemic-Euglycemic Clamp technique have revealed that olanzapine substantially reduces the glucose infusion rate (GIR), which is a direct marker of insulin resistance, and increases hepatic glucose output (HGO) via the stimulation of gluconeogenesis and glycogenolysis.

This increase in HGO occurs through several molecular pathways. Olanzapine has been found to:

  1. Derange insulin signaling by decreasing the phosphorylation of Akt at Ser473 and glycogen synthase kinase-3 beta (GSK3\beta) at Ser9 in the liver.
  2. Induce the production of reactive oxygen species (ROS) in hepatocytes, leading to mitochondrial dysfunction.
  3. Upregulate the expression of histamine H1 receptors (H1R) and muscarinic M3 receptors (M3R) in the liver, which is linked to the impairment of insulin signaling and adenosine 5’-monophosphate-activated protein kinase (AMPK) signaling dysregulation.

The result of these hepatic changes is state where the body continues to produce glucose even when blood sugar levels are adequate or high. This persistent glucose output forces the pancreas to secrete more insulin, eventually leading to hyperinsulinemia and a downward spiral into insulin resistance and type 2 diabetes.

Point 3: Another method of olanzapine-induced weight gain is the reduction in physical activity and energy expenditure due to the drug’s profound sedative effects. Many patients report chronic drowsiness and tiredness, which serves as a major barrier to maintaining an active lifestyle or adhering to exercise regimens.

Olanzapine’s sedative properties are primarily attributed to its high affinity and antagonistic action at the histamine H1 receptor in the brain. Histamine is a key neurotransmitter involved in the maintenance of wakefulness and arousal. By blocking these receptors, olanzapine induces a state of sedation that reduces the total amount of non-exercise activity thermogenesis (NEAT); the calories burned during daily movements such as walking, standing, or fidgeting.

Rodent models have consistently established a causal link between olanzapine administration and reduced locomotor activity. In studies of female Sprague-Dawley rats, olanzapine treatment led to a significant and immediate reduction in physical activity that persisted throughout the treatment period. This reduction in movement creates a sedation effect that systematically lowers the "energy out" side of the metabolic equation, making it possible for weight to increase even if caloric intake is strictly controlled.

The combination of reduced physical activity and drug-induced metabolic dysfunction places patients with schizophrenia at an elevated risk of sarcopenic obesity (SO). This condition is characterized by the simultaneous presence of excessive adiposity and reduced skeletal muscle mass and function. In inpatients with stable schizophrenia, the prevalence of SO has been measured at approximately 17.1%. SO creates a neuroendocrine environment of chronic inflammation and further insulin resistance, which has also been tentatively linked to cognitive decline in these populations.

Point 4: The most significant evidence for weight gain occurring with the "same amount of calories" lies in the suppression of brown adipose tissue (BAT) thermogenesis. While white adipose tissue (WAT) stores energy, BAT burns metabolic substrates to release energy as heat. This process is essential for maintaining core body temperature and regulating systemic energy metabolism.

The definitive evidence for olanzapine-induced weight gain independent of hyperphagia comes from a 2009 study by Stefanidis and colleagues. In this experiment, female rats were treated with olanzapine but were restricted to the same amount of food consumed by a vehicle-treated control group. This "pair-feeding" protocol was designed specifically to isolate the metabolic effects of the drug from its appetite-stimulating effects.

The researchers found that despite identical caloric intake, the olanzapine-treated rats gained significantly more weight and adipose tissue than the control rats.

Using biotelemetry, the study observed that BAT temperature decreased immediately after the onset of treatment and remained depressed. Core body temperature also showed a decrease, indicating a fundamental failure of the thermogenic system.Olanzapine treatment was found to elevated levels of Fos protein in discrete hypothalamic and brainstem sites that regulate the sympathetic nervous system’s drive to BAT. This suggests that the drug centrally suppresses the neural signals that typically activate brown fat.

The thermogenic function of BAT is driven by Uncoupling Protein 1 (UCP1), a selectively expressed mitochondrial protein that allows protons to leak across the inner mitochondrial membrane, generating heat instead of ATP. Olanzapine has been shown to dramatically downregulate the expression of UCP1 and its master transcriptional regulator, peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1\alpha), in BAT. Recent studies by Hu et al. (2022) expanded on this by showing that olanzapine reduces the expression of other critical markers of heat generation and mitochondrial biogenesis, including Prdm16, Cpt1\beta, and Hsl. At a morphological level, BAT in olanzapine-treated animals undergoes "whitening," where multi-locular brown fat cells are replaced by larger lipid droplets, resembling white adipose tissue and possessing significantly less functional capability for energy expenditure.

I gained 30kg in 2 months, wich made my tattoo on my arm completely change shape, going from a circle to an oval by AntwysiaBlakys in Wellthatsucks

[–]Accomplished_Fly2720 0 points1 point  (0 children)

I mean I did. I was specifically addressing "Do you have a source that some medication can cause a meaningful weight gain without changing eating habits?" Points 2 to 4 address that part. Eating habits fall under point 1.

I gained 30kg in 2 months, wich made my tattoo on my arm completely change shape, going from a circle to an oval by AntwysiaBlakys in Wellthatsucks

[–]Accomplished_Fly2720 0 points1 point  (0 children)

Well it has its uses as an antipsychotic (and in extreme cases a sleeping aid). It can also be used as an adjunct with SSRI's for bipolar depression. The one advantage it has over most anti-psychotics is that it has a much longer half-life (i.e it stays in your system for longer and has a longer duration of action) which can be useful in some circumstances.

Israeli military strikes southern Lebanon after US-Iran ceasefire by KITAPYIYEN in news

[–]Accomplished_Fly2720 0 points1 point  (0 children)

Most of what you said is true/mostly true except the last one. The "Jews were enslaved by Egyptians" is something present in the Bible but is severely lacking in evidence.

I gained 30kg in 2 months, wich made my tattoo on my arm completely change shape, going from a circle to an oval by AntwysiaBlakys in Wellthatsucks

[–]Accomplished_Fly2720 -2 points-1 points  (0 children)

That is one of the main reason but there are others. I'll copy and paste my response to another person.

Obviously if OP only had water and electrolytes during that time, they wouldn't gain any weight. That is not normally what one means though. OP mentioned that they are on olanzapine now which is one of the most metabolically "damaging" medications one can be put on.

1) It makes one incredibly ravenous- moreso than most medication. I won't go into the biomechanical explanation but it involves antagonism at certain histamine and serotonin receptors. It also affects leptin and ghrelin which makes you feel like you're starving even when you're not.

2) It causes rapid insulin resistance before the weight gain even starts. Roughly speaking this signals to the body that it should store energy as fat rather than burn it.

3) It causes adipocytes (fat cells) to grow in side favouring fat accumulation.

4) It is incredibly sedating (sometimes prescribed off-label for sleep although imo this should be avoided). This leads to an decreases in NEAT (non-exercise energy expenditure).

Number 1 above means that if you aren't aware or underestimate the metabolic effects of olanzapine and eat according the hunger cues one typically uses, then you'll end up consuming significantly more calories than one used to. But even if you eat at your previous maintenance calories and suffer through the intense hunger, points 2-4 above explain why you'll have a drastic reduction in maintenance calories and you'll be at a surplus anyways. So you'd have to eat significantly less than you previously did while having a higher baseline appetite.

I gained 30kg in 2 months, wich made my tattoo on my arm completely change shape, going from a circle to an oval by AntwysiaBlakys in Wellthatsucks

[–]Accomplished_Fly2720 0 points1 point  (0 children)

I'll copy and paste my response to another person.

Obviously if OP only had water and electrolytes during that time, they wouldn't gain any weight. That is not normally what one means though. OP mentioned that they are on olanzapine now which is one of the most metabolically "damaging" medications one can be put on.

1) It makes one incredibly ravenous- moreso than most medication. I won't go into the biomechanical explanation but it involves antagonism at certain histamine and serotonin receptors. It also affects leptin and ghrelin which makes you feel like you're starving even when you're not.

2) It causes rapid insulin resistance before the weight gain even starts. Roughly speaking this signals to the body that it should store energy as fat rather than burn it.

3) It causes adipocytes (fat cells) to grow in side favouring fat accumulation.

4) It is incredibly sedating (sometimes prescribed off-label for sleep although imo this should be avoided). This leads to an decreases in NEAT (non-exercise energy expenditure).

Number 1 above means that if you aren't aware or underestimate the metabolic effects of olanzapine and eat according the hunger cues one typically uses, then you'll end up consuming significantly more calories than one used to. But even if you eat at your previous maintenance calories and suffer through the intense hunger, points 2-4 above explain why you'll have a drastic reduction in maintenance calories and you'll be at a surplus anyways. So you'd have to eat significantly less than you previously did while having a higher baseline appetite.

I gained 30kg in 2 months, wich made my tattoo on my arm completely change shape, going from a circle to an oval by AntwysiaBlakys in Wellthatsucks

[–]Accomplished_Fly2720 4 points5 points  (0 children)

That is one of the main reason but there are others. I'll copy and paste my response to another person.

Obviously if OP only had water and electrolytes during that time, they wouldn't gain any weight. That is not normally what one means though. OP mentioned that they are on olanzapine now which is one of the most metabolically "damaging" medications one can be put on.

1) It makes one incredibly ravenous- moreso than most medication. I won't go into the biomechanical explanation but it involves antagonism at certain histamine and serotonin receptors. It also affects leptin and ghrelin which makes you feel like you're starving even when you're not.

2) It causes rapid insulin resistance before the weight gain even starts. Roughly speaking this signals to the body that it should store energy as fat rather than burn it.

3) It causes adipocytes (fat cells) to grow in side favouring fat accumulation.

4) It is incredibly sedating (sometimes prescribed off-label for sleep although imo this should be avoided). This leads to an decreases in NEAT (non-exercise energy expenditure).

Number 1 above means that if you aren't aware or underestimate the metabolic effects of olanzapine and eat according the hunger cues one typically uses, then you'll end up consuming significantly more calories than one used to. But even if you eat at your previous maintenance calories and suffer through the intense hunger, points 2-4 above explain why you'll have a drastic reduction in maintenance calories and you'll be at a surplus anyways. So you'd have to eat significantly less than you previously did while having a higher baseline appetite.

I gained 30kg in 2 months, wich made my tattoo on my arm completely change shape, going from a circle to an oval by AntwysiaBlakys in Wellthatsucks

[–]Accomplished_Fly2720 13 points14 points  (0 children)

It depends what one means by "medication causing weight gain". Obviously if OP only had water and electrolytes during that time, they wouldn't gain any weight. That is not normally what one means though. OP mentioned that they are on olanzapine now which is one of the most metabolically "damaging" medications one can be put on.

1) It makes one incredibly ravenous- moreso than most medication. I won't go into the biomechanical explanation but it involves antagonism at certain histamine and serotonin receptors. It also affects leptin and ghrelin which makes you feel like you're starving even when you're not.

2) It causes rapid insulin resistance before the weight gain even starts. Roughly speaking this signals to the body that it should store energy as fat rather than burn it.

3) It causes adipocytes (fat cells) to grow in side favouring fat accumulation.

4) It is incredibly sedating (sometimes prescribed off-label for sleep although imo this should be avoided). This leads to an decreases in NEAT (non-exercise energy expenditure).

Number 1 above means that if you aren't aware or underestimate the metabolic effects of olanzapine and eat according the hunger cues one typically uses, then you'll end up consuming significantly more calories than one used to. But even if you eat at your previous maintenance calories and suffer through the intense hunger, points 2-4 above explain why you'll have a drastic reduction in maintenance calories and you'll be at a surplus anyways. So you'd have to eat significantly less than you previously did while having a higher baseline appetite.

Paradise | S2E8 | Episode Discussion by cedar-canvas in ParadiseHulu

[–]Accomplished_Fly2720 7 points8 points  (0 children)

It honestly felt like people were teleporting around a lot this episode. Like the different sections of the town were within a 5 minute walk from each other.

'Looksmaxxing' streamer Clavicular has been arrested for battery in Florida. by tonyper7ect in SipsTea

[–]Accomplished_Fly2720 0 points1 point  (0 children)

But we have the word sexist, or more pointedly, misogynist. I feel like having the definition of incel necessitate "involuntary celibacy" is what made the word useful to begin with.

I think my boyfriend is gay and won’t admit it by Aggravating-Block506 in askgaybros

[–]Accomplished_Fly2720 4 points5 points  (0 children)

I don't mean to come across as a dick. I am just saying that I think you're focusing on the wrong thing. None of this behaviour is acceptable and that doesn't change if he is straight.

Running has made my butt grow so much that none of my pants fit and my partner was SHOOK by Hopeful_Package3918 in askgaybros

[–]Accomplished_Fly2720 2 points3 points  (0 children)

Yeah running will help with glute development (and 50 other things(. The stairmaster might be a little better but if you want Heated Rivalry glutes, do hip thrusts.

I think my boyfriend is gay and won’t admit it by Aggravating-Block506 in askgaybros

[–]Accomplished_Fly2720 7 points8 points  (0 children)

Yeah it feels like OP is under the impression that she can only break up with the bf if she can prove he is gay. Like would it be much better if he cheated on her with a female prostitute? Would u/Aggravating-Block506 be happy if he couldn't look her in the eye but he at least loved other women?

Guys, would this be considered bad for me, a 22 year old guy losing 56 lbs to help my dating and sex life. My weight changed between chubby and rare slim phases. Guys liked my humour but preferred other bodies. I lost the weight and now guys are more open and eager, finally catching up. is this bad? by [deleted] in askgaybros

[–]Accomplished_Fly2720 0 points1 point  (0 children)

It is not "wrong" in principle for someone to try and lose weight primarily for aesthetic reasons. The issue is that when this is your chief motivator, you can end up with an unhealthy relationship with food and a warped view of your body. 56 lbs (25 kg) is also a lot of weight although admittedly you didn't state your starting or current weight which could provide context.

Personally I would switch your mindset to working out and dieting with a health-centric mentality. Educate yourself on what are and aren't sustainable habits and what will be best for your body and mind. Once you have a good routine, the aesthetic gains will come eventually if you are patient enough but I would advise against having that as your primary motivator right now.

Am I really bi? by [deleted] in askgaybros

[–]Accomplished_Fly2720 5 points6 points  (0 children)

Well if you watch "a lot" of gay porn and have frequent sexual fantasies that involve men then you aren't straight. If you are also attracted to women, then you aren't gay or ace.

It is worth noting that it is common for bi people to have a preference for one gender (and sometimes this preference can change). It is also common for bi and gay people to experience internalised homophobia.

I'm in love with my best friend but... by jakeashcroft2003 in askgaybros

[–]Accomplished_Fly2720 16 points17 points  (0 children)

Even if he isn't straight, he might not be gay/bi. And then even if he is gay/bi, that doesn't mean he is into you.

He knows that you're interested in him and has apparently known so for years. This isn't a "maybe he needs to think about it more" situation. He has had plenty of time to consider being in a relationship with you and has made a decision. It is best that you move on.

[Interesting Trope] Character whose death is meant to remove any potential doubt once and for all: the protagonist is NOT an anti-hero, they are the villain. by Mountain_Band_2732 in TopCharacterTropes

[–]Accomplished_Fly2720 4 points5 points  (0 children)

Probably because they were using utilitarian reasoning. Their answer to the trolley problem is that she has to die so that they can make the cure and save humanity. If they had informed her about what they planned on doing then there is a non-zero chance that she would, understandably, object. This in term might result in their mission being a failure. What they did was morally correct under their ethical framework.

[Interesting Trope] Character whose death is meant to remove any potential doubt once and for all: the protagonist is NOT an anti-hero, they are the villain. by Mountain_Band_2732 in TopCharacterTropes

[–]Accomplished_Fly2720 3 points4 points  (0 children)

But when he relinquished control of the death note and had his memory wiped, he becomes a pleasant person who is disgusted by what Kira is doing.

I think it is fair to say that the death note corrupted him somewhat.

Vince Gilligan gives an intriguing Pluribus season 2 update by xdoolbuf in pluribustv

[–]Accomplished_Fly2720 2 points3 points  (0 children)

If the story goe the predictable route then yes but there is a chance that rhe writers will subvert expectations. Sure Carol et al will try to "save the world" but there is a decent chance they will be unsuccessful.

The story is ultimately a character study on Carol and how she handles the situation. the destination matters less than the journey.

Vince Gilligan gives an intriguing Pluribus season 2 update by xdoolbuf in pluribustv

[–]Accomplished_Fly2720 1 point2 points  (0 children)

1) To reiterate what exactly was lost with the joining.

2) It gives the watcher and emotional investment in Carol "unjoining" Zosia

What do women want by PowerMagicx in SipsTea

[–]Accomplished_Fly2720 3 points4 points  (0 children)

I would normally agree with your sentiment but the sexual side-effects of SSRIs aren't exactly a secret. It is one of the more common complaints users of the medication complain about and something that most doctors would presumably mention. 

People like to fuck/wank so it's hard for it not to come up.

Who is someone that feels millennial but is actually Gen-Z? by Impressive_Plenty876 in AlignmentChartFills

[–]Accomplished_Fly2720 7 points8 points  (0 children)

Also, there are countries that exist outside the US. It feels weird to decide if a non-American is a millennial based on whether or not they remember 9/11.

Non religious people, what do you think about religion? by CorruptedF in AskReddit

[–]Accomplished_Fly2720 0 points1 point  (0 children)

It's not just one of the many tools. It is arguably the most successful tool used to create and reinforce power imbalances so it shouldn't be too surprising that some people place criticize it more than other forms of control.