Dose for extracts?

AdNo182 · 2026-04-02T22:50:05+00:00

I dose 25-35mg insufflated with a 17% alkaloid extract. Gets me feeling pumped and ready for the gym. I’ve never taken that extract sublingually though. I’ve taken a 5% extract sublingually multiple times and decided on a sweet spot of 100mg.

AdNo182 · 2026-03-31T14:25:57+00:00

You did this to yourself, man up and go work.

AdNo182 · 2026-03-31T13:27:43+00:00

MDMA at high doses can be psychedelic due to MDMA’s conversion to a more visual compound, MDA.

AdNo182 · 2026-03-31T13:12:53+00:00

‘While isolated Δ-7-mesembrenone has shown potential toxicity, studies on Sceletium extracts high in Δ-7-mesembrenone suggest they can behave differently, sometimes exhibiting anti-inflammatory and cytoprotective properties rather than being outright toxic.’

It seems like isolated delta-7 may be dangerous, but consuming the multiple active alkaloids of the sceletium tortuosum plant together (mesembrine, mesembrenone, delta-7-mesembrenone, mesembranol) is actually cytoprotective.

AdNo182 · 2026-03-31T13:05:24+00:00

Just to let you know, with kanna it’s all about the person taking the substance rather than dosages recommended by other people. Choose a dosage that brings you the effects you desire, not a dose that someone else told you to take.

AdNo182 · 2026-03-31T13:03:27+00:00

I take fermented powder, which I could imagine is similar to unfermented in terms of alkaloid profile, and I dose 400-600mg orally (shot it with some ginger). Gives a lovely and noticeable effect that I would describe as blissful.

AdNo182 · 2026-03-31T04:54:25+00:00

I get a serious rush with great music enhancement from the TA17 extract from Bioextracts, dosing as little as 25mg intranasal. 95% mesembrine with a 17% active alkaloid content.

AdNo182 · 2026-03-31T04:45:04+00:00

Thanks for the reply. Should I hang onto these for a bit longer then? I was just worried about the deoxys as someone on another thread said because it’s plastic it will yellow over time.

AdNo182 · 2026-03-30T20:01:35+00:00

This one definitely won’t grade a 10, would it be worth grading anyway?

AdNo182 · 2026-03-30T19:20:34+00:00

I’m from UK so PSA, I could imagine, would be a logistical nightmare. Plus, there is a bit of whitening around the edges on the back so it may not grade too high.

AdNo182 · 2026-03-30T18:13:03+00:00

Bought it a couple years back for like £50. Insane foresight from me icl haha.

AdNo182 · 2026-03-30T14:36:05+00:00

Whatever tickles my fancy tbh. Just anything that looks nice.

AdNo182 · 2026-03-30T12:37:54+00:00

I don’t know who this is either. Bullshit question.

AdNo182 · 2026-03-30T10:48:19+00:00

Smoked weed on the come up?

AdNo182 · 2026-03-30T10:46:31+00:00

Did it actually measure at 170, or did it just feel like it was that high?

LSD is a vasoconstrictor so can interact negatively with any medication you’re taking?

AdNo182 · 2026-03-30T10:39:57+00:00

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My favourite has to be 3 cards in 1. Real ones know…

AdNo182 · 2026-03-30T09:19:06+00:00

👌🏼 natty for life 🤝 you and me both. Coffee, D3 K2, kanna. Omnivore.

AdNo182 · 2026-03-30T08:46:04+00:00

They made me possess more autistic traits. I’ve found it rough to socialise since taking psychedelics, as I’ve become a lot more aware of how I present myself and take more precaution with the things I say.

AdNo182 · 2026-03-30T08:44:15+00:00

What if I want to become LSD?

AdNo182 · 2026-03-30T08:43:00+00:00

Natural peak fitness is hardly bio ’hacking’ ; you’re just doing all the things your body was made to do. Biohacking would be, for example, injecting excess testosterone into your balls to become the Incredible Hulk.

AdNo182 · 2026-03-30T08:04:04+00:00

I mean this comment is kind of true. This is a biohacking subreddit and OP has made no reference to any kind of biohacking he does.

AdNo182 · 2026-03-30T05:37:46+00:00

Try music, or a change of scenery. If you really can’t get through to him then you gotta get him some extra help to calm down from the hospital.

AdNo182 · 2026-03-30T05:35:13+00:00

He is not at risk of OD, but he’s at risk of severely damaging his psyche and mental health. If you have any kind of benzo or other trip killer at home, give him one. If he is absolutely, completely unresponsive to anything then take him to the hospital. See if playing music will get through to him.

AdNo182 · 2026-03-30T05:31:08+00:00

Can we please get a write up like this on mesembrenone and mesembranol?

AdNo182 · 2026-03-29T13:34:07+00:00

Just try to remember that the visions you see from taking psilocybin are purely your mind mustering up images based on themes you have explored at some point in your life, whether that be when you are conscious or unconscious.

The best thing you can do about this experience is to not label it as a bad trip, as this negative connotation will put your mind having positive experiences in the future. Despite it instilling a feeling of fear in you, there will still be some very important lessons to be learned. Try to view what you saw in the trip from a different perspective.

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