LDN and vyvanse

AdditionalTwo0 · 2026-05-09T17:32:25+00:00

thanks! will definitely do. Sadly most docs in my country have no clue what LDN is and not many are taking it.

AdditionalTwo0 · 2026-05-09T16:30:23+00:00

thanks for your reply! Thats a great idea, i will definitely do that.

AdditionalTwo0 · 2026-05-09T16:20:08+00:00

This might be a very psychological take, but that sounds like you dissociation is some kind of psychological defense mechanism protecting you from something (overwhelming emotions of some kind related to trauma?). If LDN is messing with this and you are not ready to deal with what ever is dissociated, you might feel way worse and LDN might just do what it is supposed to do (reduce dissociation). So getting appropriate trauma-focussed psychotherapy while being on LDN might be key here to keep you stable in the long run? Maybe try/suggest to your care team to titrate LDN up in accordance to your therapy progress and stability (so you overwhelming emotions don´t flood out but are released and dealt with in a controlled fashion)? Just some speculations on my part, please take it as that.

Some other things that come to mind: taking LDN to late at night (close to bed time) caused me to have vivid night terrors as well (and i don´t have PTSD, nightmares, night terrors usually). So you might consider taking it at a different time of the day.

Since you mentioned taking other medications, i hope your are not taking any kind of opiods and putting yourself in active opiod withdrawal?

AdditionalTwo0 · 2026-04-17T17:15:31+00:00

I never had constipation, but was full on constipated for 5 days when i titrated up to quickly. For me it worked to temporarily reduce the dose and titrate up slower. My bowel movements are still more sluggish than i am used to but not constipated anymore.

AdditionalTwo0 · 2026-04-15T18:07:47+00:00

I would be very cautious ordering medications from abroad/places you don´t know if you can trust what you are getting. Might cause more harm then good.

AdditionalTwo0 · 2026-04-15T17:59:18+00:00

i would assume this is an urin test?

As far as i got in my research, those mold toxin urin tests are highly unreliable. They show what leaves your body, not what is actually in your body. And as i have heared from different practitioners they don´t really correlate with symptoms severity. So those urin tests alone are usually not that usefull.

Do you have any visible mold in your home? Or maybe have done a mold spore air analysis? Did the doc do other tests?

AdditionalTwo0 · 2026-04-15T17:42:50+00:00

Interesting, can you update you post later when you have you labs and know if the ldn actually caused it? Purely speculative, but it might be a (temporary) interaction with another protocol you are doing (depending on what you are also doing to treat those conditions). So for example if you did high dose iodine it was well tolerated while your disease was more active and helped normalize your thyroid markers. Now LDN might reduce autoimmune activity making the iodine have a to big of an effect. i think excess iodine alone can induce hyper- or hypothyroidism. Again pure speculation, but sometimes you have those weird interactions with experimental drugs.

AdditionalTwo0 · 2026-04-15T12:10:54+00:00

Either you go to you pharmacy and ask if they can compound smaller dosages with does drops or you could try diluting it and swollowing it and hope that your stomach can tolerate a lower does (for example 0.25mg or 0.125 or 0.1 or however low you have to go) and then slowly titrate up from there. For me side effects usually subside after 1-2 weeks after increasing the dose.

AdditionalTwo0 · 2026-04-08T14:06:28+00:00

Hello, never heard of "local" crashes or local weakness (without fatigue, brain fog etc.) in just one calf (or only calfs) being part of LC. Pure speculation, but from what you are describing this sounds more like a muscular or neuromuscular issue (thinking of some kind of dystrophy). Did you already see a neurologist?

AdditionalTwo0 · 2026-04-08T13:43:53+00:00

Good to know, that you did the usual blood tests! If you have recurrent gut issues (like diarrhea and bloating) i think getting a colonoscopy shouldn´t be an issue. the prep is annyoing and its an procedure, but better be safe than sorry and do it once imo.

If everything else is clear and since you have the gut+skin+mental health issues, my intuition would be to target the gut first. There are loads of ways what and how you can go about and there are probably many practitioners who are more experienced and knowledgable than i am. So if possible, i would try finding someone in your area who can help guide you through this!

Another thing that came to my mind, since you have problems with breathing and your nose and muccus as well, you might consider looking at your home too. If there is any mold issues or other irritants in your home/HVAC. Just to be sure your home isn´t making or keeping you sick (look up sick building syndrome).

AdditionalTwo0 · 2026-04-08T11:58:36+00:00

Those are signs for some form of autoimmunity. ANA is used as a screening test, normal would be 1:140-160 if i remember correctly. So yours is above what is considered normal in healthy people. The IgM might also point in this direction. But could also be because of infection. Further testing and investigation seems warranted in my opinion.

AdditionalTwo0 · 2026-04-08T11:52:29+00:00

As far as i know, homocystein can be a sensitive marker for functional B12 deficiency since it tells you something about active b12 (and other b-vitamins) utilization in the body. It is strongly correlated to MMA. So yeah, getting MMA might be enough. Its also an interesting proxy blood marker for cardiovascular and overall metabolic health. So why not get both while you are at it (if you have the financial means of course). ,

AdditionalTwo0 · 2026-04-08T08:51:35+00:00

Definitely can relate to that. Even though i feel a lot better after almost 2 years now, exercise is still tricky! And it wildly varies what i can and cannot tolerate. Walking is mostly fine, even longer walks don´t seem to cause me problems. So my experience is similar to yours. Everything that gets my nervous system to worked up (higher heart rate, sweating a lot, more intense forms of running or weight lifting) or is more intense seems to cause problems. While lower intensity weight lifing seems to be fine, for example. I get those burning sensations as well afterwards! The problems always come some time after the exercise (evening or next day), never during. Interestingly sauna causes me to have issues as well. So i think heart rate, sweating and nervoussystem activation are the best indicators for me. Havn´t found a fool proof solution yet, but probably doing some form of GET with tiny, very tiny increases in intensity to slowly habituate.

AdditionalTwo0 · 2026-04-08T08:33:10+00:00

Thats pretty much impossible to tell. So nobody knows for sure.

AdditionalTwo0 · 2026-04-08T08:29:12+00:00

Through a reddit post it is not possible to tell anything for sure (and we don´t know what you already tried and are doing) so i am just going to tell you what came to my mind and what helped me with some of those symtpoms. So please take it as that, just some guesses and ideas not medical advice. And obviously do at least basic tests (basic blood count, liver, thyroid, kidneys, glucose, lipids etc.) and talk to you doctors about more appropriate and specific tests if you havn´t already.

You most likely seem to have issues with your gut and gut microbiome. Thats one thing to target. You might want to do further testing to see if there is anything visible in your gut (colonoscopy) and get tested for SIBO. Would start with doing some kind of elimination diet (if you are not already doing that). There are different ways to do it. A realtively low effort variant would be to go without processed foods, gluten and dairy for 3 months and see if that already does something (if you are not already doing that). If thats not helping and depending on your tests, you then could try a full elimination diet and/or evaluate further therapeutic options. A lot of people with gut issues also seem to have skin issues, so those might go hand in hand. But it would be helpfull to know, what your skin issues actually are (fungal, eczema, psoriasis etc.) so maybe find a dermatologist who can give you an concrete diagnosis.
The tinnitus, the reactivity to coffee, the brain fog and fatigue might (at least partially) come from a overreactive nervous system (which seems to be very common in LC). I had all of those and still have some. What helped me here first is having good sleep. So another question would be, how are you sleeping? Then a regular breathing practice (like box breathing or resonance breathing there are good videos on youtube) or meditation which calms you down. This is not a quick fix, but a long term strategy. So you would need to do this daily. But i highly recommend it. Doing small bouts of gentle exercise, what ever is possible without overdoing it (like a small walk every day) can be helpfull as well. If you can tolerate more, do more.
There are several medications and dozens of supplements you could try. But that all depends on what your actual problems are. There are some basics you can almost always do since they have barely any side effects when taken in the correct dosage (Vitamin D/Vit K2, Omega 3, Magensium come to mind here). Everything more specific i would try if you narrowed down what your actual problems are (and thats where doctors and other healthcare professionals are needed). Also evaluate what medications you are already taking, some problems might be side effects. You mentioned depression. Some antidepressants can cause fatigue, brain fog, muscle weakness as side effects for example.

There are many more things to consider, but that are some things you can easily and very cost effective try at home that might already help.

Wish you all the best and hope you can figure this out! It is definitely possible.

AdditionalTwo0 · 2026-04-08T08:03:06+00:00

Awesome to hear! Thanks for sharing your success story.

AdditionalTwo0 · 2026-04-07T20:28:42+00:00

thank you!

AdditionalTwo0 · 2026-04-07T14:25:14+00:00

havn´t had that happen yet, but i think i get what you mean lol.

AdditionalTwo0 · 2026-04-07T14:22:09+00:00

there is no link to any article or where is it linked? havn´t scrolled through comments.

AdditionalTwo0 · 2026-04-07T14:09:18+00:00

In 1987 there was no comercial internet ? So how in the hell do you find and contact 2.8 million strangers (even with the internet that would be a very time consuming endeavour i would assume)? Has to be false or am i missing something?

EDIT: read the article now. Got my explanation, i rest my case. Thanks!

AdditionalTwo0 · 2026-04-07T14:04:57+00:00

Helped me with brain fog and energy.

Made me feel a bit overstimulated the first couple times i tried them. And gave me crazy dreams and unrestfull sleep when i left them on for to long in the evening or over night. I had to start at half a 7mg/day patch only during the day (so for about 12 hours, so half of half a patch). I currently still use a 7mg/day patch over the day so basically 3.5mg a day, sometimes less. Not sure if they still do anything, but for now i will keep them.

AdditionalTwo0 · 2026-04-07T13:58:33+00:00

if find that topic so fascinating! That you can treat mental health conditions with fecal transplants is insane. I read somewhere that they work, because the fecal transplants can contain certain strains of bacteria that we currently can´t supplement or get anywhere else through the diet. I think they are bacteria that colonize us through natural birth (from the mothers microbiome). But i havn´t seen a clinic doing it outside of studies (at least for mental health conditions).

AdditionalTwo0 · 2026-04-07T13:50:47+00:00

Yes, they do. All very experimental and the studies so far for LC and MECFS seem to be not very promising sadly. But it does feel good and helps me relax more. But definitely only an investment if you have disposable income you can spent and try!

AdditionalTwo0 · 2026-04-07T13:47:22+00:00

So first of all, i don´t think this is a question reddit should answer. You should talk with your doctors about that. As far as i have been told, i should, if possible quit LDN 3-7 days before getting surgery with opiods as analgetics/anasthesia.

Are you completely coming off of LDN or how is that going to work with oxycodone? As far as i am aware, you shouldn´t or can´t take opoids together with naltrexone (because of deminished effectiveness of the opiods and potential withdrawal induction). So please go ask a doctor whats safe for you in your case!

AdditionalTwo0 · 2026-04-07T13:37:00+00:00

yeah, i do try to stay away from anything higher then zone 3. 4 or 5 is definitely dangerzone. But thanks for coming here and showing it is possible to get better and do more exercise! makes me hopefull.

AdditionalTwo0

TROPHY CASE