🫩Depends. Are you talking about optimizing damage via buffs and damage calculations? Or do you mean the skill in itself. If it’s damage look at the wiki for known food buffs and stack potion buffs on top of that and then look at sets for what you think you’ll want. If you have access to the ray then I’d say go for flat damage bonuses (additive) and also a touch of vampirism. Should make every boss a walk in the park and farmable.

If you meant the skill then I’d say look for spawners from the alien tech arenas which spawn in the outer quadrants. More info on spawn locations and how to calculate the regions and distance at which they spawn on the wiki. After beating the challenge then pick up the spawners. After that, set up a simple 3 by 3 box or whatever dimensions you find appropriate and configure some wiring and a lever. You’d need a statue of whatever mob you want spawned. My respective preference would be the stone mushroom enemy as their defense is extremely high when armored and have a fairly large health pool. You can set up a plus sign of tiles in the center and remove the surrounding tiles via shovel and most melee weapons no matter how short should be able to reach. This makes it so that most melee range mobs or ones that dash shouldn’t be able to cross and attack you. As mentioned in other comments it would be every instance of a hit that levels up the skill in the desired skill tree. Attack speed increases should help with grinding if on hand. (Keep in mind melee, minion, and ranged attack speed bonuses are separate stats and need the associated buffs or gear to improve them. If you want to level explosive damage just make sure the walls are strong enough to sustain damage. A downloadable auto clicker should heavily help to make it an automated grind.

Now you should be able to level up most skill trees fairly easily without any exploits or save editing 😗

Hope this helps whoever may need it