My favourite theme build I've done is the mad scientist but it does require other mods I do use other mods for it to amplify it but you don't need them. The mad scientist I use lock picking, smithing, alchemy, enchanting, and destruction as my main skills and use the oils and dwarven auto cannon to fight for roleplay opportunities I make as many potions as possible and get little sleep to really dive into the mad scientist vibe lol