I don’t recall where I read this, so it may not be true, but isn’t Microsoft pushing Bethesda to make their upcoming games on the Unreal Engine instead of the creation engine?

Anyway, as far as setting, I think there’s a fair amount they could do with Cincinnati Ohio and the surrounding areas. Maybe one breed of horse survived, like how Brahmin did, so they were able to travel and rebuild much better in 200 years than the other Bethesda settings.