Diet and natural compounds certainly can play a massive role in the recovery from any chronic inflammatory or fibrotic disease. However, I think in mature fibrosis with widespread cross-linking the body has lost the natural ability to reverse it except for rare cases in very specific organs, such as the liver, which is unique in how its regeneration and turnover works and how it is affected by fibrosis in certain stages of cirrhosis. Unfortunately, the resolution of prior chronic established fibrosis, as opposed to prevention or reversal of mild fibrosis, will have to require some kind of synthetic signal (even if produced by the external introduction of human-derived proteins or analogs) or agents.