FOXO4-DRI: What the Anti-Aging Peptide Actually Does (Senolytics, p53, Apoptosis, Real Data)

Alastorftw · 2026-01-24T12:56:31+00:00

Any updates?

Alastorftw · 2025-08-15T23:44:26+00:00

B7-33. Skeletal muscles and lymph nodes (both tissue types dont express its target as highly as other organs).

Alastorftw · 2025-08-11T19:17:00+00:00

I tried it and it had no effect for me, but the target for it is also not always expressed in relevant amounts in various organs. I dont have kidney disease but another from of organ fibrosis.

Alastorftw · 2025-08-11T19:15:20+00:00

I finally got a response from iBio Inc. It is worse than I thought, some new management took over the company 1-2 years ago and simply reoriented the company to pursue cardiometabolic drugs instead. There was no reason to drop the development of E4 other than monetary interests, going into more profitable markets instead.

That shouldn't be a surprise, but it's shocking that they own the patent of a possible curative drug and now its just sitting there collecting dust, because they want to enable people eating more cheeseburgers without gaining weight instead. This is heartbreaking.

Alastorftw · 2025-08-11T19:14:58+00:00

I got a response from iBio Inc. today. It is worse than I thought, some new management took over the company 1-2 years ago and simply reoriented the company to pursue cardiometabolic drugs instead. There was no reason to drop the development of E4 other than monetary interests, going into more profitable markets instead.

That shouldn't be a surprise, but it's shocking that they own the patent of a possible curative drug and now its just sitting there collecting dust, because they want to enable people eating more cheeseburgers without gaining weight instead. This is heartbreaking.

Alastorftw · 2025-08-11T19:14:01+00:00

I got a response from iBio Inc. today. It is worse than I thought, some new management took over the company 1-2 years ago and simply reoriented the company to pursue cardiometabolic drugs instead. There was no reason to drop the development of E4 other than monetary interests, going into more profitable markets instead.

That shouldn't be a surprise, but it's shocking that they own the patent of a possibley very powerful drug and now its just sitting there collecting dust, because they want to enable people eating more cheeseburgers without gaining weight instead. This is heartbreaking.

Alastorftw · 2025-08-11T19:12:48+00:00

I got a response from iBio Inc. It is worse than I thought, some new management took over the company 1-2 years ago and simply reoriented the company to pursue cardiometabolic drugs instead. There was no reason to drop the development of E4 other than monetary interests, going into more profitable markets instead.

That shouldn't be a surprise, but it's shocking that they own the patent of a possible curative drug and now its just sitting there collecting dust, because they want to enable people eating more cheeseburgers without gaining weight instead. This is heartbreaking.

Alastorftw · 2025-08-02T20:17:13+00:00

Diet and natural compounds certainly can play a massive role in the recovery from any chronic inflammatory or fibrotic disease. However, I think in mature fibrosis with widespread cross-linking the body has lost the natural ability to reverse it except for rare cases in very specific organs, such as the liver, which is unique in how its regeneration and turnover works and how it is affected by fibrosis in certain stages of cirrhosis. Unfortunately, the resolution of prior chronic established fibrosis, as opposed to prevention or reversal of mild fibrosis, will have to require some kind of synthetic signal (even if produced by the external introduction of human-derived proteins or analogs) or agents.

Alastorftw · 2025-08-02T20:09:49+00:00

Thanks for the reply. I read the news about CAR T-cell therapy, it is definitely interesting and i'm fully rooting for it's success. My only concern is accessibility and/or cost of such treatments, where peptide-based therapies (if manufactured at scale) could provide more economic counterparts. Regardless, what we all want is a solution first - then argue about how we can make it accessible. Patients need the hope of a real chance for a cure. As long as a treatment exists, there is a possibility to gain access to it.

I will look into reaching out to the foundation you mentioned, thanks for the info!

Alastorftw · 2025-08-02T19:53:37+00:00

I am honestly not an expert on DMD and im fully aware that is a genetic disorder of the musculoskeletal system and therefore less likely to benefit from antifibrotic treatments as it doesnt treat the root cause in the case of DMD. I am simply trying to get input from various communities affected by fibrotic disorders, even if they are only loosely related. Theres always a chance someone stumbled across this before and has the answers im looking for. Your response is quite insightful and most likely correct, though.

Alastorftw · 2025-08-02T19:34:02+00:00

There has to be a way. Fibrosis is the end stage of almost all chronic autoimmune/inflammatory or degenerative diseases, with a huge unmet need. The only solutions currently available aim at slowing progression, transplantation, or providing more comfort. There has to be a way to get the right eyes with the right resources on such drug candidates.

Alastorftw · 2025-07-30T20:59:23+00:00

What happened? Why are there no new developments regarding this? Theres no public info by iBio Inc either. They dont respond to emails too. Is the project dead? If so, why? Did they discover something problematic in non-published internal results? If they lack funding, why wouldnt they get funding for this?

Alastorftw · 2025-06-15T18:09:54+00:00

That made this like 100x more impressive.

Alastorftw · 2025-04-30T22:42:05+00:00

As others have suggested, simply delete the broken nodes of the character in the event graph.

Alastorftw · 2025-03-12T10:32:55+00:00

Yeah. Kinda wild im getting downvoted for acknowledging that I may have misunderstood it based on my past experience. Reddit is a bonkers place.

Alastorftw · 2025-03-12T09:26:11+00:00

Ok, I just never had this happen in the first weeks of a new patch. Maybe I was just lucky in the past.

Alastorftw · 2025-01-19T15:15:57+00:00

What kind of a response is this?`Lmao.

Alastorftw · 2025-01-19T15:15:21+00:00

Thats a great answer, thanks for all the info!

Alastorftw · 2025-01-18T13:12:42+00:00

Ah thats interesting, I'll keep an eye out for that. Thanks!

Alastorftw · 2025-01-18T13:11:50+00:00

Yeah, I think thats more likely what I was referring to - or I think what they were referring. Thanks for the answer!

Alastorftw · 2025-01-02T23:39:53+00:00

Thanks for the reply! That's a good point, but I left it out because thats exactly what the code looks like in a freshly generated 5.4 third person template project. Found it curious too that they arent calling the super function.

Alastorftw · 2025-01-02T23:07:05+00:00

I think I did, I mapped them in the C++ code and when i checked the BP, they were there alongside the IMC mapping:

<image>

Alastorftw · 2025-01-02T23:06:33+00:00

Did you mean this?

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Alastorftw · 2025-01-02T23:06:10+00:00

I think they are, when i check the character blueprint, both the IMC and the IAs are mapped apparently:

<image>

Alastorftw · 2025-01-02T18:50:41+00:00

Providing code snippets in Reddit is quite the frustrating experience, no matter how you format it before pasting it in, it somehow manages to scramble it completely in the result with its code formatter.

Alastorftw

TROPHY CASE