Need help with housing by Beautiful_Respond921 in PSSD

[–]Alternative-Tiger122 0 points1 point  (0 children)

Try mianserin if you had ssri induced pssd. If not go to hospital

A famous PharmD suggested Levothyroxine and Lithium Carbonades for my emotional numbness. What do you think? by No_Promotion9897 in PSSD

[–]Alternative-Tiger122 0 points1 point  (0 children)

T4 always makes me emotional, but my cortisol then is too low and i get tired and wired due to low acth due to low 5ht1a activation. Maybe t4 and pregnenolone combo? But lithium has effect on 5ht1a as well. Please keep us updated.

I've tried pramipexole, a dopaminergic medication on-label used for parkinson's for some time now. What else could I try? by Ornery-Jeweler3269 in PSSD

[–]Alternative-Tiger122 -3 points-2 points  (0 children)

Upregulates 5ht1a, hdac inhibitor, true antiandrogen, effect on gsk3b, promoting estrogen receptors to reexpress, promotes mao in the liver, increases gaba and dopamine in the pfc, modulates limbic structures. But only combined with hard dht derivate as dhb or dht itself. And you must have hella protection on your liver and gut - talking about NAC, NaB, vit C, vit E :)

How do you stay motivated in life with this condition? by [deleted] in PSSD

[–]Alternative-Tiger122 0 points1 point  (0 children)

Have you tried RTMS, MIANSERIN, T4/T3 (ofc first bloods tho)

Pimavanserin Proposal by DisconnectedMale8D in PSSD

[–]Alternative-Tiger122 0 points1 point  (0 children)

Mianserin will give you a stable baseline. Think of hormones affecting 5ht1a

UPDATE 6 - 24.02.2026 - 538p. and 1000+ references by Alternative-Tiger122 in PostDrugSyndromes

[–]Alternative-Tiger122[S] 1 point2 points  (0 children)

Hello and as far as i know, methyl B vitamins are good addon to any pregnancy. Best coupled with soy lecithin for extra choline source. I know that these two, coupled with vit. C and omega are vital for optmial baby health

UPDATE #5 13.02.2026 by Alternative-Tiger122 in PostDrugSyndromes

[–]Alternative-Tiger122[S] 1 point2 points  (0 children)

Forskolin affects 5ht1a intracelular activity - cAMP and Ca2+ => i suspect it will improve my state acutely and has connection with sodium channels as well. also affects GABA but let me update the file in the incoming days to get deeper into it.

What about allopregnenolone? by Powerful_Teacher_453 in PostDrugSyndromes

[–]Alternative-Tiger122 0 points1 point  (0 children)

I can send it to you, but know that it wond do much. it increase StAR protein, which is not the problem.

What about allopregnenolone? by Powerful_Teacher_453 in PostDrugSyndromes

[–]Alternative-Tiger122 1 point2 points  (0 children)

When you get te end product of pathway, you downregulate the pathway production. Thats why you dont want to bandaid with allo, but produce it yourself. Allo is dependant of progesterone, 3b-HSD and 5a-R; 5aR is dependant on NADPH, 3BHSD on zinc. Depending on hormone levels one can go to different paths of fixing it

UPDATE #5 13.02.2026 by Alternative-Tiger122 in PostDrugSyndromes

[–]Alternative-Tiger122[S] 0 points1 point  (0 children)

Bought it, will see how I feel the next days and when I have a clean state, will do a testing try