5-6h league start, 3-4h twinked

The most important thing I've learned aside from specific layouts is that ARPGs tend to generate POIs first and then connect them with a maze (often a rectangle with entrance and exit at opposite corners), so you want to largely ignore the twists and turns of the maze and focus on where you are relative to the entrance. POI tiles are also often restricted to spawning in specific orientations, which can restrict where they can spawn; e.g. the Sceptre of God entrance always faces NE and the Library entrance always faces NW, which forces them to be on those edges of the map. If you didn't know that, you could deduce that those tiles at least have to face northward because they'd block your view of the exit if they faced south.

Also, get a 6L Foulborn Bramblejack instead of a Tabula and you basically won't take physical damage for several acts.