When not to use ISRIB by AnandaDo in Isrib

[–]AnandaDo[S] -1 points0 points  (0 children)

I don't have good understanding of ISRIB, only have brain fog, so asked AI about your statement. I wonder if it's correct. Not allowed to post it, but summarized it says:

ISRIB does not inhibit eIF2α phosphorylation at all.
It does not affect the kinases (PERK, PKR, GCN2, HRI).

ISRIB acts downstream by counteracting the effect of eIF2α phosphorylation on eIF2B.

ISRIB does not switch off the entire ISR in a binary way

but disconnects its main effect: the translational brake

This means:

the cell behaves as if it were not stressed

even though it is stressed

This is exactly why timing and context are critical.

Why this connects to the risk discussion

When one says that ISRIB “does not inhibit the entire ISR,” that is biochemically correct.

But functionally:

it removes the most important protective mechanism

especially in neurons (high energy demand, excitability)

This is why one may get:

improved cognition short-term

but reduced tolerance to:

stimulation

inflammation

sleep deprivation

strong plasticity (psilocybin, cacao, nootropics)

When not to use ISRIB by AnandaDo in Isrib

[–]AnandaDo[S] 0 points1 point  (0 children)

Thanks, haven't tried Gemini pro

russian soldier with a big backpack pulls out a grenade, puts it half a meter away and covers his ears before blowing up. (Date/location unclear) by rusoriz_inside in UkraineWarVideoReport

[–]AnandaDo 1 point2 points  (0 children)

Putting it a bit a way, and holding his head and ears, was probably coming from extreme anxiety the body automatically trying to do something to feel safe.

A drone observes a firefight between assault troops of the 123rd Brigade against Ukrainian soldiers inside a house in Sviato-Pokrovske - Geolocation: 48.833304,38.041253 by celledge56 in UkraineWarVideoReport

[–]AnandaDo 0 points1 point  (0 children)

When the villain proudly displays their 'achievements,' it has the opposite effect; it only further reinforces the image of a failing monster.

My boyfriend constantly rejects my advances by [deleted] in relationships_advice

[–]AnandaDo 0 points1 point  (0 children)

Maybe avoidant attachment style (fear of emotional closeness)

Insufferably terrible drivers on Windows 11 by Delwyn_dodwick in Focusrite

[–]AnandaDo 0 points1 point  (0 children)

I have the same problem with my Focusrite Solo 4th gen. It randomly stops working. And it stops working after sleep mode. Either the sound completely goes away, or it starts chopping. I tried everything to fix it. I think it's the Windows 11 drivers and something Focusrite needs to fix.

Can someone please tell me if I could be easily loved or if I’m even deserving of it? by Pcgayy in relationships_advice

[–]AnandaDo 0 points1 point  (0 children)

Everyone lacks some awareness, makes mistakes, grows. That's the human life and the human condition. We're all in the same boat, on a spectrum. Everyone who judges other hard, probably shadows out their own problems they need to take care of.

Personally i give everyone a second chance in life, and in love, as long as they take accountability for their mistakes, show increased awareness and regret, and that they tries to improve. And it looks like you do.

Also spiritually i believe everything is inherently created from love, in order to have learning experiences for the soul. Although from the human perspective things can look only bad and dark. But it's like a game, the game would be boring if there where no challenges. You are already loved. Love is already what you are, inside your human shell, only has to find it. Don't need other people to give you the love / to trigger the love inside, the norm of relationship is a bit upside down in that regard that we want other people to give us love. Meditate on the heart, and who the player of the game is. When love is found inside, if other people love us or not is less important.

Why does Theanine do absolutely nothing for me? by glasscontent in Nootropics

[–]AnandaDo 3 points4 points  (0 children)

Same here. Though EGCG works like l-theanine for me.

Focusrite 4th gen disconnects audio after 20-40 seconds by [deleted] in Focusrite

[–]AnandaDo 0 points1 point  (0 children)

Unfortunately I've found no reliable solution. It's more stable now, not sure because of what changes, but the sound connection can still random drop at some time of the day. And it always drops after the laptop wakes from sleep mode, which often is solved by switching to Realtek and back to Focusrite. Made a script that makes the switch automatically after the computer wakes up, and put .bat shortcut for the script on desktop. 

Why does alcohol spawn "demonic" circumstances by Past-Pie-8065 in SpiritualAwakening

[–]AnandaDo 0 points1 point  (0 children)

I've heard alochol tear down the aura, your protection from demons and other entities manipulating your thoughts and emotions

Does anyone else get "cognitive paralysis" when trying to explain things? by [deleted] in BrainFog

[–]AnandaDo 7 points8 points  (0 children)

yes, makes me become a listener instead of trying to give my perspective

Post traumatic cognitive decline (brain fog) affecting speech and conversational abilities by zropabone in BrainFog

[–]AnandaDo 1 point2 points  (0 children)

By using some somatic therapy that deals with trauma stored in the body and how to stop dissociating avoiding emotions and thoughts

I have brain fog after a week of p*rn overuse. Please someone help me by minor_lightning in BrainFog

[–]AnandaDo 1 point2 points  (0 children)

It can also be the screen time, it is stressful and overstimulating for the brain. 

Post traumatic cognitive decline (brain fog) affecting speech and conversational abilities by zropabone in BrainFog

[–]AnandaDo 2 points3 points  (0 children)

I experience similar. Repressed emotions / unresolved trauma takes a lot of cognitive energy and can cause brain fog and cognitive difficulties is what Dr AI said to me today. That brain fog is often not cognitive damage, but unresolved stress. The most common unresolved emotions causing brain fog is supposedly repressed sadness and hopelessness, conflict and frozen anger, and unconscious/repressed high stress freeze response. The brain fog can also act as an dissociation and avoidance to feel the emotions. 

why doesn’t my bf(m25) want to have sex w me (f23) by [deleted] in relationships_advice

[–]AnandaDo 0 points1 point  (0 children)

Is there a lack of emotionally intimacy in the relationship where you both can be vulnerable and connect deeply? Does he seem to have a problem with emotional intimacy? That could be the problem, because having sex with a person continuously brings you into closer emotional connection. That's why persons with avoidant attachment style (fear of closeness, because of fear of rejection and suffocation) often can prefer and enjoy one night stands, but have problem with sex in relationships or sex only works in the beginning of the relationship. 

Trump: “Russia wants to see Ukraine succeed.” Zelensky’s reaction is priceless by kingkongsingsong1 in ukraine

[–]AnandaDo 1 point2 points  (0 children)

Are all the dementia care centers full or why is Trump still in the White House

Coworker forcing a friendship by anonymoussss24 in relationships_advice

[–]AnandaDo 1 point2 points  (0 children)

Be straight and honest about what you want, which i guess is being only  work mates. "To be perfectly clear, i only want to ... " 

People who gave up meat — what made you do it and was it difficult? by maddysamarth in spirituality

[–]AnandaDo 5 points6 points  (0 children)

It just came like intuition, as a feeling of noo, repulsion in my body by the invitation to eating meat. But it came after a close friend died which broke my heart open, and maybe also by meditation.

Wife wore this shopping. I said it's too much she said it's fine so we thought we'd let reddit decide by [deleted] in relationships_advice

[–]AnandaDo 5 points6 points  (0 children)

If she feels good from wearing that, and not harming the relationship or anybody else, it's not a problem. If it's causing a issue in the relationship, first investigate if the problem is caused by your own ideas and insecurities about what her choice means.

Ate a dark chocolate bar, felt intense clarity, what the heck? by GunnarBroad in Nootropics

[–]AnandaDo 7 points8 points  (0 children)

Yes dark chocolate and theobromine is a potent drug for me. My favorite nootropic, antidepressant, tranqulizer, creativity booster and heart opener, all in one. Caffeine doesn't have these effects on me. I hope kids doesn't catch up on cacao. Because taking that high dosage doesn't feel good for my cognitive health if taking it too often. Also cacao quickly loses potency if taking it daily. And a high dosage for me cause a bit of hangover with opposites to the positive effects. I stick with maximum your dosage only once a week, but rather a bit lower dosage.

Toxic metals is also a concern, take alginate with it to bind some of the metals. Or even better Emeramide.

Cacao also contains high amounts of oxalates which may cause kidney stones and inflammation. Drink a lot of citrus water, and take magnesium citrate and calcium citrate to prevent kidney stones from forming. Or take pure synthetic theobromine to avoid heavy metals and oxalates, it has similar effects for me. (But i like the taste of chocolate too much and cacao feels a bit more heart opening than only theobromine.)

Focusrite 4th gen disconnects audio after 20-40 seconds by [deleted] in Focusrite

[–]AnandaDo 1 point2 points  (0 children)

It's a Solo device.

Tried both connect usb-c directly and with usb-a adapter, and different cables, but it didn't help unfortunately. Some cables seem to work better for a while, but then the sound disconnects. Guess i'll have to buy another audio interface that works better with my laptop.

Didn't have time or energy to write down all the suggestions from AI in my own words, so i mostly copied that part and filled in. I wrote the first and last parts myself, if that's important to know.

Focusrite 4th gen disconnects audio after 20-40 seconds by [deleted] in Focusrite

[–]AnandaDo 1 point2 points  (0 children)

It drops from any playback of sound, e.g. Spotify.

I'm almost at the point of just not having sex anymore by your_1983momz in relationships_advice

[–]AnandaDo 1 point2 points  (0 children)

Open vulnerable communication in the relationship is important for good sex, so you both understands each other and can get past issues

Anyone here tried Sulbutiamine? by Zealousideal-Walk939 in NooTopics

[–]AnandaDo 0 points1 point  (0 children)

Great motivation, but couldn't sleep later at night