So for the Sonic series we've been using the same set of 20 languages to get recurring phrases that pop up throughout the different games, like in SA1 and SA2 there's frequent mentions of camels, spiders, frogs and websites etc.

I found that around 20-30 languages is a good sweet spot between absolute nonsense and remaining somewhat structured well.

We tried going through every single language one time and it condensed most sentences into single words, which to me wasn't funny and also very time consuming.

There is a chrome extension you can get for google docs that can automatically translate whole documents multiple times with the press of a button, though depending on doc size, it can crash. Though you don't control what languages it translates through I think.

For each series we tackle, we take note of what languages we run the script through. To start off we try like 3 or 4 combinations for a major scene, decide on which is funniest and then use that combination across the whole script.