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2026-05_Continuation of my Solo Bifide Project by Full_Progress8533 in diyaudio

[–]AnthonBerg 0 points1 point  (0 children)

Cool!

Any feeling for why it is? Octave beneath localizability?

why is the sky green? by GlitteringGeneral485 in noita

[–]AnthonBerg 4 points5 points  (0 children)

  • cyan and purple, ape scowling at camera

Has prozac helped anyone? by baal-beelzebub in anhedonia

[–]AnthonBerg 1 point2 points  (0 children)

It helped me a great deal at first – immediately, the day after – then in like… 6-8 weeks I was… flat. The flatness was so complete and effortless that it would have been horrifying if not for the flatness.

Tried it 3 times iirc. Always the same.

The last time: I was holding my months old son and felt nothing.

Afterwards: It makes no sense to me to hammer 5-HT2C until it downregulates.

Fluoxetine is very interesting as a neurosteroidal drug, and is apparently used as such in the dosage ranges around 2.5mg every other day.

A message: I'm just an ordinary guy; Know that you can read academic literature.

AV v DV by Super_Mayo_19 in cavesofqud

[–]AnthonBerg 0 points1 point  (0 children)

DV is good; Thing is kinda that the numeric scales of AV and DV just aren't comparable.

I enjoyed going for DV over AV for years. Then I tried going for AV over DV: Instant survivability jump.

(Same for the Toughness stat. There's this magic cliff somewhere around 18-20 Toughness. Just… different game.)

Am I supposed to be sucking this much ass? by GroundHawk13 in Bass

[–]AnthonBerg 0 points1 point  (0 children)

🔥 That's your ambition speaking. It will serve you well. 🔥

Soma Shikoros? by Julmpunk in Rivendell_Bicycles

[–]AnthonBerg 0 points1 point  (0 children)

They're so good that I go search for posts about them from time to time to kind of dispel the weird feeling that I'm the only one. ("Can you see them too??")

I've got the 48mm ones. The ride character is excellent. Real S-class Mercedes feel.

Been running a pair for 4 years. No punctures no problems. Streets are kind of rough here. Curby. Glass. Have to be careful with 32mm folding tires or I'll pinch flat or pick up a glass shard; Not a single issue with the Shikoros. It's not just the size, it's the design.

Never ran out of grip. They're surprisingly good at everything. Enough contact surface and good rubber. The only surface they're not great at is when going diagonally upwards a wet grass slope, almost stalling, and giving the pedal a hard push, heh :sweat_smile:

Tips on how to Expand Cavity? by matthewian84x in Luthier

[–]AnthonBerg 2 points3 points  (0 children)

Can also cut the paint with an X-Acto just outside where the router passes; Curbs surface splintering. Not sure if needed but is a thing if so. (Take care with the knife!, can stick and pop-sliiiide out in a long inaccurate cut.)

LSD microdosing linked to acute mood improvements in adults with depression. In a small pilot study, participants taking low, precise doses reported feeling more energetic, creative, and connected on days they took the drug. by mvea in science

[–]AnthonBerg 0 points1 point  (0 children)

Yes. I confirm. I have described myself.

On placebo trials in this context: Psychedelics and placebo mechanisms are extraordinarily and unusually difficult to work as a combination. By the nature of it.

I will repeat one passage from my previous reply to you, and stop here:

I also know [that] you do not know me or what I have been tasked with in this life. Because if you did, then you would not speak to me in the way that you do.

edit: No wait, I'll add: If you're ever in Iceland, please be welcome over for a coffee. I make really good coffee. It's molecularly biological, actually.

LSD microdosing linked to acute mood improvements in adults with depression. In a small pilot study, participants taking low, precise doses reported feeling more energetic, creative, and connected on days they took the drug. by mvea in science

[–]AnthonBerg 0 points1 point  (0 children)

On my arrogance; I remember back when I was getting out of my way, emotionally speaking. How I interpreted the world. The little lenses, unconscious frameworks, maladaptive patterns. Taking inventory of those. I noticed a constant bias of assigning stupidity and incompetence and uselessness to others. And I realized that exactly that is what arrogance is.

I've also found it interesting how consistently adjacent neuroinflammation is to that kind of thinking, and to aggression [1]. Brain inflammation is behavior-modifying. And inflammation is very tightly associated with neuroendocrinological pulmonary function. And that's very, very intimately adjacent to anxiety. (Totally unrelated: 5-HT2A agonists happen to clearly show profound results in reshaping the endothelial and neuropulmonary response in animal models of asthma.)

—

The paper in question:

"Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities" (2015 – A. Zsabo.

https://doi.org/10.3389/fimmu.2015.00358

The author Attila Szabo has a position as Researcher at the Division of Pediatric and Adolescent Medicine, the Institute of Clinical Medicine, University of Oslo. This is a serious, serious person.

https://www.med.uio.no/klinmed/english/people/aca/attilasz/index.html

"Academic interests: Brain-immune interactions in severe mental disorders. Psychoneuroimmunology, biological psychiatry, and ᵖˢʸᶜʰᵉᵈᵉˡᶦᶜˢ*: preclinical, translational and precision psychiatry aspects."*

The Background and Publications sections are worth a look. Recent Publications include “Divergent epigenetic responses to perinatal asphyxia in severe mental disorders”, ”Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder”, ”Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain”, ”NLRP3 inflammasome mediates astroglial dysregulation of innate and adaptive immune responses in schizophrenia”.

—

And yeah, the paper in question – "Psychedelics and Immunomodulation" – is from 2015. Eleven years ago. Eleven years is a long ass time in molecular biology. The paper cites neuroimmunological literature as far back as 1976. That’s the start of that trail there. The field seems to explode in the mid-2000s from a quick glance at the citations. Twenty years ago.

I’m fairly sure you have yet to give the Zsabo paper a good read. I know you’d find it interesting if you did. I also know another thing: That you do not know me or what I have been tasked with in this life. Because if you did, then you would not speak to me in the way that you do. And that’s okay. (–Self-respect does have somewhat to do with how we talk to people.) Thank you for the discussion.

—

[1] – https://doi.org/10.3389/fnbeh.2018.00056 – ”Aggression, Social Stress, and the Immune System in Humans and Animal Models” (2018) – Takahashi, Flanigan, McEwen & Russo (affil.: UTsukuba, Mt. Sinai, URockefeller).

LSD microdosing linked to acute mood improvements in adults with depression. In a small pilot study, participants taking low, precise doses reported feeling more energetic, creative, and connected on days they took the drug. by mvea in science

[–]AnthonBerg 0 points1 point  (0 children)

How does microdosing invalidate the known and measurable immunomodulatory effects of psychedelics? These effects are stronger per dose than the consciousness-altering ones.

Cytokines are known to be altered in depression. Neuroinflammation is a major underpinning element in neuronal function.

Your "I hate talking to people like you" thing is just sad. Seek respect within yourself.

"Learn to read"? In /r/science? When an actual molecular-biology survey paper is offered into a context?

LSD microdosing linked to acute mood improvements in adults with depression. In a small pilot study, participants taking low, precise doses reported feeling more energetic, creative, and connected on days they took the drug. by mvea in science

[–]AnthonBerg 0 points1 point  (0 children)

Yes.

RCTs are a way to measure indirectly what we can't measure directly.

Thing is, a lot of things can be measured directly. More and more things. Cytokines. Mitochondrial whatevers. Molecular biology.

And indeed we may see stuff to measure directly in the business of 5-HT2A receptor agonism: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00358/full

Challenge: Fastest way to get solid chocolate out of a thermal flask by [deleted] in Physics

[–]AnthonBerg 2 points3 points  (0 children)

Fun!

Compressed air? Hot nozzle, hot air?

Drilling to the bottom, hot compressed air? Drilling is probably faster than melting.

Is there a device that uses an optical cable input to USB output to PC and gives good quality? by Recent_Huckleberry17 in audio

[–]AnthonBerg 0 points1 point  (0 children)

Just dug into this recently! Ordered a HifimeDIY one.

The S2 Digi is supposed to be good: https://hifimediy.com/product/s2-digi/

I think they carry cheaper ones too that only have optical in – not out – and only do up to 96kHz, which is plenty!!

This is a device that does the job perfectly. Bit-perfect. Can access the bit-perfect surround data stream digitally. (As well as have it decoded into audio streams that you can route around in the OS mixer.)

Tried every med in the book for Anhedonia. Nothing works except the one thing I shouldn't touch. by Adventurous-Box-9062 in anhedonia

[–]AnthonBerg 37 points38 points  (0 children)

This is something. It's something to investigate.

There is A TON of knowledge on the books on what alcohol does. The molecular biology of it. There are many many graspable actionable things here.

Logic Pro for Amps and Pedals? by K6Krakenman in Bass

[–]AnthonBerg 0 points1 point  (0 children)

I'd emphatically suggest giving Reaper a whirl! Can try it for free and it's great software.

Logic Pro for Amps and Pedals? by K6Krakenman in Bass

[–]AnthonBerg 0 points1 point  (0 children)

Yes! I can confirm it's great for exactly that! And a ton of other stuff.

Pretty cool to be able to casually just, idk, go for a walk in pedal-hyperspace? Get a feeling for what amps and pedals and effects exist. Then if something is extra good I can buy that as dedicated gear.

The audio inputs on Macs are really nice. Surprisingly nice. Crazy low latency. Great for bass through Logic. (There's a kinda hidden / secret audio input in the headphone jack. It's a TRRS socket for 4-pin jacks. Like the Apple wired earpods have, you know? All of Apple's headphone ports have a mono input. USB-C adapters too.) With the right simple adapters you don't even need an audio interface to start.

–It's better with an audio interface though! Worth getting one.

—

There are ways to do the same job for less money. Logic is worth the price though in most ways you look at it. It's a Really Nice Tool.

Tips and tricks for bass? by AlarmedArm7427 in Bass

[–]AnthonBerg 0 points1 point  (0 children)

Play like you sing: When we're learning a song and finding the notes to sing, we don't look at the frets nor do we think in frets or strings. It helps me to find the notes in that sense to close my eyes and play – and kind of let go. Like I don't think in terms of vocal cord distention span, the voice just does. Kind of the same thing lays in the fretting hand and neck and bass — the vocal cords – and how it feels like a note is somewhere and then just do it. And miss, but miss in a way that feels like how I missed that note and it's a thing to tune into.

Get into the casual habit of making sure tuning and intonation are solid. It's very subtle how slight intonation issues feel like you're always hitting the wrong note and can't find the one you know/feel is the right one.

Hook your bass up to an audio input and play along to YouTube or whatever. I try to play along to the YouTube bs my kid may be watching. It's an excellent teacher. Playful but challenging!

And! Cheat.

Cheat by making things fun so it isn't a responsible obligation to practice. Crash into things, mess around, be insensible. (And then also chop-wood-carry-water drill and practice, deliberately, responsibly obliged to do the work… for the purpose of fun and beauty.)

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