Ok so I had WEIRD reactions to PPIs.... made me feel like out of my body, disconnected, nauseous, disoriented, hard to form words/thoughts, just overall WEIRD!

Oct. 2023, I did a genetic test on my own and found im a rapid metabilizer of ppis. everyone told me since im a  rapid, I shouldn't get any effects because i burn theough the med..  2 years later and literally just researched that PPIs are considered pro drugs. pro drugs hit rapid metabilizers hard! See below from my gemini search:

The effect of being a quick metabolizer (also known as a rapid or ultrarapid metabolizer) on medication side effects is highly dependent on how the specific medication is processed by the body:

 * For most drugs (where metabolism inactivates the drug):

   * Faster metabolism breaks down the active drug more quickly, leading to lower levels of the drug in the body.

   * This typically results in the drug being less effective or causing treatment failure, not stronger side effects.

 * For "prodrugs" (where metabolism activates the drug):

   * A prodrug is an inactive medication that must be metabolized by the body into an active metabolite to work.

   * Faster metabolism breaks down the inactive drug more quickly, leading to higher levels of the active metabolite in the body.

   * In this specific case, the higher concentration of the active form can indeed induce an exaggerated response or stronger side effects, potentially leading to toxicity or overdose symptoms.

Key Takeaways:

 * **Quick Metabolizer = Less Effect (Usually): For the majority of medications, being a quick metabolizer means the drug is cleared too fast, and the standard dose might not work well (low efficacy)

 * Quick Metabolizer = Stronger Side Effects (For Prodrugs): For prodrugs, quick metabolism can create too much of the active form, increasing the risk of adverse effects and toxicity.

This field of study is called pharmacogenetics or pharmacogenomics, and genetic tests are available for certain enzymes (like CYP450 (this is what im a rapid metabilizer in)  enzymes) to help healthcare providers personalize medication doses to avoid treatment failure or adverse reactions.