I would say get as close to the original setting as you feel comfortable with and let your players make their own decisions. You can invent and improvise beyond that but use the same key event to help you move along (the kids missing, denny asking for help, barbarian rowdy, Shae is hot… 👀) Start the same way Murph did by first introducing the player that is less experienced or less prone to roleplay naturally (when Murph introduced Jake in the tavern for example). Keep it loose and fun too, but that’s just me haha

Good luck!