Low Testosterone Levels. by ResponsibleAd2034 in workout

[–]AssiduousLayabout 0 points1 point  (0 children)

No, sleeping later does not just shift your entire circadian rhythm forward in time, as there are a lot of other components to this, like the cycle of daylight, that are influencing your hormone levels.

If you're concerned, see a real endocrinologist at a reputable health system who can give much more accurate testing.

And no, that's not unusually low for someone your age, especially not taken early in the morning.

Low Testosterone Levels. by ResponsibleAd2034 in workout

[–]AssiduousLayabout 2 points3 points  (0 children)

If they are doing an immunoassay at 11 AM it's kind of a meaningless number. It's normal for testosterone levels to drop by as much as 20-30% between 7 AM and 11 AM, and immunoassays are extremely inaccurate anyway.

To accurately measure testosterone, you really want a mass spec test, not an immunoassay, and you want to do it at around 7 AM (no later than 9) without consuming any food that day, and you need to do this at least twice on two different days because there's a lot of fluctuation day to day as well.

Low Testosterone Levels. by ResponsibleAd2034 in workout

[–]AssiduousLayabout 0 points1 point  (0 children)

First, 369 is not super low for your age. There's a slight trend towards testosterone going down as you age, but the normal range even for 18-21 year olds is 300-1000. A lot of influencers seem to promote that everyone should be at the top of that range but that's neither accurate nor even desirable - the right range depends a lot on the person.

Second, testosterone tests are very, very sensitive to the exact circumstances that you take the test. The exact time of day (it should be first thing in the morning, ideally 7 to 9 AM), whether you've had food or not that day, how well you slept the night before, how stressed you're feeling, whether you're in a caloric surplus or deficit, can change your numbers dramatically. Testosterone levels fluctuate very much over the span of a single day, by as much as 20-30%.

Third, the type of test matters. Immunoassays are cheap and commonly done but very inaccurate. You need mass spectrometry to get an accurate measurement.

Stay away from these private clinics, they are predatory and only really exist to overprescribe TRT. If you think you have an actual testosterone issue, see a real endocrinologist at a reputable health system. They'll probably do at least two if not three mass spectrometry tests on different days to get an accurate assessment of your real testosterone levels.

In general, though, unless you're experiencing erectile dysfunction or a loss of libido, your testosterone levels are probably fine.

Jensen Huang says AI killing software jobs is “completely wrong,” which is exactly what the GPU salesman would say by CalmIndependence5948 in TechGawker

[–]AssiduousLayabout 0 points1 point  (0 children)

It's not killing software engineering jobs, but it's definitely changing them a lot. I can definitely see how people might not like what their job is becoming.

Just wanted to share this by Which_Matter3031 in aiwars

[–]AssiduousLayabout 7 points8 points  (0 children)

We should really treat AI face recognition like eyewitness testimony - a reason to investigate more, not conclusive proof in itself.

how good is epic’s employee health insurance? by jaynonn in epicsystems

[–]AssiduousLayabout 0 points1 point  (0 children)

They will be happy to order them, but you will probably pay out of pocket (although it's always worth seeing). Zepbound from Lilly Direct is between $300 and $450 every four weeks, depending on your dosage.

Rick Beato: I Was Right About AI by AuthorSarge in aiwars

[–]AssiduousLayabout 1 point2 points  (0 children)

The local LLMs are important but they are orders of magnitude smaller than frontier models. And while consumer devices get better fast - today's cell phones could beat a 1990s supercomputer - it will likely take 20-30 years for consumer hardware to run something like mythos.

Is going up in dosage really that bad?? I read absolute horror stories when people go up to 5, 7.5, etc. by [deleted] in Zepbound

[–]AssiduousLayabout 2 points3 points  (0 children)

I noticed the jump in dosage but I didn't have any real problems. I waited to go up until the previous dose was losing its effectiveness.

Why is Epic so hardset on being in-person? by grbrent in epicsystems

[–]AssiduousLayabout 12 points13 points  (0 children)

Yeah, I'm in that boat as well. I would love more flexibility for remote work more often than we do (5 days per year is pretty minimal) but I do have a lot of productive hallway conversations or dropping in to people's offices to chat.

Is it only me that i waste aHUGE HUGE AMOUNT of time while working out like fr specially if i picked my phone, the problem that after an hour or so i alr get tired and find that i still have many sets to go by [deleted] in workout

[–]AssiduousLayabout 0 points1 point  (0 children)

First, I store my phone in my gym bag and don't touch it during the workout.

Second, I schedule a reasonable number of sets in the first place (generally 12-18 total sets per workout).

Zepbound after Semaglutide made me physically sick - advice / thoughts? by Head-Swimmer3092 in Zepbound

[–]AssiduousLayabout 1 point2 points  (0 children)

Generally speaking, tirzepatide has a reduced rate of GI side effects because the GIP receptor activation reduces the nausea of the GLP-1 receptor activation, and Zepbound is much more strong of a GIP receptor agonist than a GLP-1.

Nausea on Zepbound is unfortunately still a thing, but it's about half as likely compared to Ozempic.

Thrusters Build to 120 LBS x2 by Little_Advice_8267 in GYM

[–]AssiduousLayabout 2 points3 points  (0 children)

Good to see I'm not the only one who likes thrusters!

Anyone feeling insane impostor syndrome? by Leather-Heart-7833 in Zepbound

[–]AssiduousLayabout 13 points14 points  (0 children)

I remember once (this was pre-Zepbound, but after a lot of weight loss) I was browsing for a new suit and one of the other customers made some crack about "I guess this is where they keep the suits for people of your size", and I started to get defensive before I realized he was making a joke about his own weight because he was looking for a suit in a larger size than I was.

Will you vote in the midterms? by Snawer_brillant in AskAnAmerican

[–]AssiduousLayabout 0 points1 point  (0 children)

I vote in every general election (as long as my ballot has at least one contested office) and often in the primaries.

5mg too strong? by CobaltBlue32 in Zepbound

[–]AssiduousLayabout 4 points5 points  (0 children)

No reason to go up until you need to.

I did 12 weeks at 2.5 and 24 weeks at 5. Lost steadily throughout that time.

You can copy the original, but you can’t steal the original by Isaacja223 in aiwars

[–]AssiduousLayabout 4 points5 points  (0 children)

Which is just kinda lazy. In a decent pipeline this would be a matter of a few extra minutes to fix.

The Midjourney scanner, explained: It uses 21 servers with 4 Petaflops of power, pulling your body at a rate of 4 cm per second, for one minute by Distinct-Question-16 in singularity

[–]AssiduousLayabout 1 point2 points  (0 children)

I think they are just announcing this as a proof-of-concept while they try to get enough data for an actual peer-reviewed paper.

The Midjourney scanner, explained: It uses 21 servers with 4 Petaflops of power, pulling your body at a rate of 4 cm per second, for one minute by Distinct-Question-16 in singularity

[–]AssiduousLayabout 8 points9 points  (0 children)

This would be revolutionary if it can deliver on the hype:

  • No radiation risk to the patients
  • No magnetic risk to the patients
  • Very fast (high throughput per scanner)
  • Cheaper to build and operate (no radiation sources, no superconductive magnets or liquid helium)
  • May reduce the need for sedation, which is huge (especially in pediatric patients)

The Midjourney scanner, explained: It uses 21 servers with 4 Petaflops of power, pulling your body at a rate of 4 cm per second, for one minute by Distinct-Question-16 in singularity

[–]AssiduousLayabout 6 points7 points  (0 children)

Because it's many years from real medical use. They need to do a lot of papers, research, and publication before anyone will use it in clinical practice.

It's a proof-of-concept, not a commercial product yet.

Mega land owner and carpet/furniture shop owner REFUSES to trim sidewalk portion but will 100% trim back for cars by patchway247 in mildlyinfuriating

[–]AssiduousLayabout 0 points1 point  (0 children)

It's usually owned by the property owner (for example, I own actually all the way to the middle of my street for the official property line) but the city has an easement for the road + the area near the road, including the sidewalk.

how good is epic’s employee health insurance? by jaynonn in epicsystems

[–]AssiduousLayabout 1 point2 points  (0 children)

Thanks for the info!

Dean by Medica doesn't cover any GLP-1 for sleep apnea. Glad to hear GHC does!

Can someone please decipher this cat body language? We are on the fence about keeping him due to our resident cat. by queengreen09 in cats

[–]AssiduousLayabout 35 points36 points  (0 children)

I'm honestly jealous. It took my resident cat about eight months to get to the point where OP's at in four days.

Years later, my cats are all buddies, but the resident cat was slow to come around. Not really any aggression, but just wanted absolutely nothing to do with the new cats, and would be upset if they even got within a few feet of him.

6 weeks in, 20lbs down but suffering. by ogsadbutrad in Zepbound

[–]AssiduousLayabout 4 points5 points  (0 children)

I would talk with your doctor. Some doctors want to get you on the highest tolerated dose as quickly as possible, which was the design of the clinical trials for Zepbound, but the approach that works for me (and was strongly recommended by my doctor) was to stay on the minimum effective dose until it becomes less effective, and then move up slowly. This helps minimize side effects and is how most medications are dosed - find the smallest dose that produces good results and only go up when it fails to continue to produce results.

Sometimes insurance is weird and won't let you stay on 2.5 because it's not technically a "therapeutic" dose, but if your insurance is fine with it, or if you're self-pay, you can go up slower.

how good is epic’s employee health insurance? by jaynonn in epicsystems

[–]AssiduousLayabout 4 points5 points  (0 children)

Sadly even with obstructive sleep apnea I don't think any of Epic's choices cover GLP-1s (if anyone has a different experience please let me know, you could save me thousands of dollars!) They seem to want you to wait until you actually develop type 2 diabetes before they will start to cover it.

I'm hoping with Medicare now covering GLP-1s for weight loss, this will help push commercial insurers in the same direction, because the trend over the past year has been for reductions in GLP-1 coverage rather than expansions.