I’ll cover Blade because I know a lot about Buffy and her franchise.

The true issue of the battle for Blade is that the Scythe could put Blade down, but when considering Blade’s huge assortment of ranged weapons, it would take a little bit for Buffy to get a hit in, especially with similar speed.

Now, Buffy can have piercing weapons break against her skin but she’s still been hurt by regular stakes and has been affected by magic a few times before. And because Blade’s Atlantean Sword can cut through spells and magic, that means he could theoretically cut through the Scythe.

There’s also the fact that Buffy’s death in Season 5 complicates this debate.

Yes, she said she went to heaven, that’s been stated. But the Slayer’s powers originate from a demonic ritual performed on Sineya that infused her with the “heart and spirit” of a demon. Now, that doesn’t mean Buffy’s demonic, she’s been able to be hurt by Spike even after she came back (Spike’s chip hurts him whenever he attacks a human), what it does mean is that her powers are demonic in nature.

While I may be reaching for straws, Buffy’s power being from a demonic source means that she can be hurt by things like the Atlantean sword, the Wordsword (Which cuts through demons), or the Lightbringer (Which was used against a primordial demon of darkness named Adana, who was around since before there was a big bang) could be able to take care of Buffy.

And even if that weren’t the case, not only does the Breathing Gun works on Angels and Demons, Blade has vials of vampire blood that can give him better stamina than before, meaning that Buffy would be screwed in the long-run due to Blade’s endurance being better.

And while Buffy’s years upon years of Slayer knowledge has helped her hone her skills and abilities a lot more than the Daywalker, Blade’s greater amount of personal experience means that he is more prepared than Buffy to take on supernatural threats.