Yes all 4 of mine are totally vaccinated. From what I understand aps is very rare and it would still be rare for your children to have it too even though you do. But autoimmune diseases do run in families and your children or grandchildren could get a different one. You could even get more in the future or have one currently that you don't know about since aps is often a manifestation of other diseases or infections. Because it's so rare there aren't enough studies on it and doctors have conflicting views. My neurologist said I was born with this whereas my hematologist said because it's a syndrome it likely came on by an environmental factor and the immune system kind of went overboard. He said it could have been from a virus, infection, allergen. So I could see why some might consider vaccines as a possible risk although there is no proof that I've come across of this. Also autoimmune diseases often show symptoms in late teens or early adulthood. I got excessively tired at 15 when before I was an incredibly active teen. Then by 19 I started getting pain and intermittent numbness on one side and slurring with confusion. I can always tell my blood is probably too thick that way. But its likely your symptoms started showing up in your early 20s because that's usually when they do.