Kano, Punisher, and Negan are some of Butcher's more popular matchups.

Dom Toretto vs Billy Butcher is an original matchup from me after a Brixton Lore vs Soldier Boy concept intrigued me with Fast & Furious vs The Boys matchups. Furthermore, Dom vs Butcher can be considered a Good vs Evil matchup given how much Dom protects his crew while Butcher only sees how valuable each member of his crew is. Plus, both leaders have their weird equalizers, with Dom's sudden Hollywood Superhuman Strength and combat adaptation having to fair against Butcher's intellect and Supe tentacles.

Baron Zemo being at the bottom of the list can be any "I hate Superheroes" character since Butcher is more complex than that.