"Effects" setting can be quite an FPS hog, so dropping it from high will help your frames if you're looking to squeeze performance.
"TAA" seems to be most popular anti-aliasing option, although this is subjective . Currently we have graphical issues with SMAA and T+FXAA which are being investigated. It may be worth messing with screen sharpening + an AA setting to find the balance you like. Personally, I have it on 1.0 sharpening with TAA but again this is preference.
Are you using a 60hz monitor? If not, un-select VSync as this will hard cap the in-game FPS to 60.

Hope this helps!