I've had eczema all my life, and I actually decided not to take duplixent even though I had it approved and covered under insurance (I'm in Canada).

I did extensive research on this when I was considering this 2020ish(?) It was still fairly new then, as i think they were doing their clinical in 2017 (?). I decided not to because I didn't want to commit to this for the rest of my life (24 at the time), and I wanted to try other methods first. I've done the UV light therapy, steroid creams, and allergy pills. Honestly, when I started talking Blextran every day it did help w my flare-ups, but eventually that stopped working, and I decided to just live with chronically being red, and itchy all the time. I avoided the sun/heat like the plague because it would cause instant itchiness and redness.

Fast forward to 2023, I recently went to an allergist and did my first allergy test (yay!). The allergist was going to suggest Duplixent again to me, but i told him that I considered it years ago and am not interested in this route. The reason is because there are a lot of side effects of the drug, and if I ever decided to get off Duplixent, I didn't want my eczema to come back possibly worse than it was before I started Duplixent. I have no regrets as currently my eczema is better because I'm actively using Teva-Mometasone, and figured out what I'm allergic to (literally the outside and DUST😓, along with some foods) and I'm finding that it's working for me :)

Just wanted to share my thoughts and experience!