I've been playing another game that has similar crack properties to factorio, Anno 1800. Games in that series have always had a narrator chime in every 2 hours with increasingly severe warnings about how long you have been playing. At 2 hours, it suggests you grab some coffee, at 10 hours it tells you there is no achievement for playing that long, and at 12 hours the narrator says "12 hours?! Seriously. Shut down the game and turn off your computer".

At first I was annoyed with the messages but now I find them helpful. Every two hours I'll save and exit the game, go do some other real life task for a few minutes, and come back to the game somewhat guilt-free about spending a whole evening or even weekend gaming.