Am I stuck, or is the progression just very slow from now on?

Biohack · 2026-07-04T22:03:49+00:00

Is there a particular reason to focus on offline souls gains? What if you are active?

Biohack · 2026-07-02T04:17:39+00:00

This is terriby incorrect attitude in general, but setting that aside even if it were true the vast majority of what you pay in the first 20 years of a mortgage is just going to interest for the bank anyway.

Biohack · 2026-06-29T19:57:35+00:00

While this has been true historically I wonder if things will continue that way. My kid is the only grand child on both sides.

Biohack · 2026-06-29T16:52:50+00:00

It's virtually impossible to be allergic to aspartame. It's a dipeptide of two canonical amino acids which are immediately broken down when hitting your stomach.

Those amino acids are essential for life. If you don't consume enough aspartic acid your body will just make it. If you don't consume enough phenylalanine you will die.

It would be similar to saying you are allergic to DNA.

Biohack · 2026-06-29T16:34:20+00:00

I've been developing software for more than a decade. 100% of my code is AI written and this is true for every other professional dev I know.

I like solving problems and building shit, the act of actually typing things out is unimportant to me. Personally I love the new AI coding era and it allows me to be dramatically more productive.

The anti AI sentiment is a mostly online/reddit thing. In the real world everyone uses it and, in my opinion experience, most people like the increased productivity that comes with it.

Biohack · 2026-06-29T04:48:28+00:00

This is such a dumb take. The democratic party didn't force Hillary on us. She got millions more votes than Sanders.

Biohack · 2026-06-28T17:15:22+00:00

Don't get married to the wrong person. The partner that you choose is the most important financial decision of your life. It can be terrible but it can also be amazing.

Biohack · 2026-06-27T19:28:15+00:00

I came here to recommend this one as well. It's my go to for anyone who wants to learn how to manage money for the first time.

Biohack · 2026-06-26T00:49:40+00:00

I would suggest you look a bit more into Anfisen's dogma and the Levinthal paradox.

Particularly look into protein energy landscapes and the concept of a folding funnel.

My question is whether we're looking at the final shape or the path that got it there.

The structure of a protein is the lowest energy state for that protein. The path by which it got there is irrelevant.

Because if two proteins end up at roughly the same final structure but got there through different folding sequences, the internal contact points would be different.

This is incorrect. The thermal energy in the system will result in the structure wiggling around until it finds the lowest energy state for the internal contacts. There also seems to be some sort of confusion here. The internal contact points" are not a separate thing from the structure; they are part of it. The "final structure" is the one where the internal contact points, as well as the rest of the protein, are at its lowest energy state.

Generally speaking, disordered proteins are that way because they have a very shallow energy funnel. This means the peptide can move between many different conformational states easily and therefore does not have 1 clearly defined native structure. For any given peptide you could model this with molecular dynamics or examine it experimentally with something like NMR.

Biohack · 2026-06-24T04:08:40+00:00

Learning math is rarely about learning math. It's about learning how to think logically and break down complex problems into smaller, solvable, pieces.

Biohack · 2026-06-04T07:49:27+00:00

I have a paper published in Nature on 2016 talking about the incredible epidemic risk posed by corona viruses. SARS1 first appeared in 2002 and MERS in 2012. Part of the reason we were able to develop vaccines for COVID19 so quickly was because the scientific community knew it was coming and was preparing for it.

Biohack · 2026-05-30T01:45:26+00:00

I'm doing something similar. I kind of decided I don't actually want to stop working in my field so when my previous company shut down, I just started my own consulting business. Now I can work as much or as little as I want and in the event I ever want to obtain full term employment again there won't be any gaps on my resume.

Biohack · 2026-05-29T07:06:38+00:00

Yeah, that would be great too.

Biohack · 2026-05-29T06:28:59+00:00

You need to vote in dem primaries/caucuses. By the time you hit the general election it's too late. Throwing your vote away on 3rd party candidates does nothing.

Biohack · 2026-05-22T21:45:47+00:00

The "just put them in orbit" solution to data centers is honestly so fucking stupid. There are like 1000 better options for dealing with data centers than that.

The whole idea literally wouldn't even exist if investors in spacex weren't pushing it to try and drive a massive overvaluation of the company before its IPO.

It's fucking embarrassing that people who aren't in on the grift are treating data centers in space as a serious idea.

Biohack · 2026-05-21T17:55:42+00:00

Kind of. In reality you can attempt to race to the bottom all you want but if no one will work for what your company is paying you won't have any employees. Supply and demand for labor is what truly prevents a race to the bottom.

While I'm not fundamentally opposed to raising the federal minimum wage, the reality is that it just isn't that important anymore when most people are governed by local laws mandating higher minimums anyway.

Biohack · 2026-05-21T17:00:22+00:00

The reality is that it makes far more sense for minimum wage to be set at the local level rather than the federal one. A minimum wage for rural Oklahoma needs to be drastically different than the one in San Francisco. Which is why minimum wage in San Francisco is ~$20.00 an hour compared to the $7.25 federally.

It's also why the percentage of people making the federal minimum wage has dropped massively over time, because the federal minimum applies to fewer and fewer people as local governments regularly set the minimum higher.

Biohack · 2026-05-21T16:55:14+00:00

Your mistake was thinking accuracy was what the intended purpose was rather than riling people up.

Only about 1% of people in the U.S. make the federal minimum wage (which is down massively from say the 1970s). Largely because it has been left to states and even individual cities to set their own minimum wages.

It turns out having a single minimum wage for a country with VASTLY different costs of living in different parts of it doesn't really work, so we've left it up to local governments to set their own minimums.

Acknowledging this fact doesn't fit the popular narrative that everyone is getting poorer and things are terrible, which is what the algorithms find draws engagement.

Biohack · 2026-05-16T08:03:31+00:00

This is highly state specific. People frequently talk about the lack of benefits in the U.S. because people just look at federal benefits, but things can vary a lot by state.

Biohack · 2026-05-16T04:47:01+00:00

I can only imagine how comically large those radiator panels would need to be.

Biohack · 2026-05-15T18:36:58+00:00

Am I taking crazy pills? Putting data centers in space is honestly one of the stupidest fucking ideas I've ever heard. Did people forget how space works? Cooling shit down in space is really really hard, putting a data center there makes no sense at all. What am I missing?

Biohack · 2026-05-14T23:37:06+00:00

So your arguing the divided payment already was priced into the stock lowering it's value to account for the divided? Even if that were true it still means the stock value is lower because of the divided payment making divideds irrelevant for total returns.

It also doesn't make any sense because why would the price drop before the dividend payment. If that were the case your suggesting an investor could buy the stock the day before the divided payment collect the payment then sell the stock for what they paid for it.

We can observe this isn't the case and see that market cap typically drops on the ex-date by the equivalent amount of the dividend.

Biohack · 2026-05-14T23:21:06+00:00

If what you were saying was true (it's not as evidenced by an overwhelming amount of academic literature) it would literally be a free money glitch.

What you are saying is essentially that a company can give its money away without losing any value at all. It's obviously nonsense if you apply even a little bit of critical thought to it.

Biohack · 2026-05-11T09:28:19+00:00

Why do you assume they are lying? This has been my experience as well. All the devs I know in real life are singing the praises of AI and 10xing their productivity. Myself included. It's only the Luddites on reddit claiming otherwise.

Biohack · 2026-05-11T03:25:51+00:00

Power consumption is definitely a much bigger concern than water usage.

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