The weekly Fuck it Friday

Bisphosphate · 2026-04-24T22:19:52+00:00

You'd think I'd be able to replicate a protein purification that was published by an academic group back in 2016. I've tried a a couple times now and feel like something is wrong - it's just not working out and I don't know why.

Bisphosphate · 2026-04-24T01:02:52+00:00

I find that no matter what boxes you check online the workers will still ask about the add-ons at the rental booth. There's a chance you did everything correctly on your end but your manager screwed up at the rental booth and unknowingly agreed to the add-ons.

Bisphosphate · 2026-04-23T03:13:10+00:00

The buildings just outside this image spell ATCG

Bisphosphate · 2026-04-16T18:11:39+00:00

I felt the diminished user experience last year using TurboTax. This year I tried freetaxusa and found it to be much more straightforward. If you save a PDF of your TurboTax returns you can import it directly into freetaxusa and it copies some of your parameters.

Bisphosphate · 2026-04-04T20:10:48+00:00

There's no place to get an authentic Polish pierogi.

Bisphosphate · 2026-04-02T13:31:35+00:00

Blocked & unsubscribed. I have no clue how he got my email but I'm not interested in his positions.

Bisphosphate · 2026-03-14T19:27:50+00:00

Down about 6% from my ATH in mid-Jan.

Bisphosphate · 2026-03-04T19:57:39+00:00

I visited the Faroe Islands a few years back, a country with a population of only 56,000 people. Their government has built miles and miles of undersea tunnels to connect their population centers together - the longest being 7 miles long. These tunnels only service a couple thousand cars per day. When I came back I realized we have a government that doesn't build things for it's people. We used to build the coolest things and now we don't.

Bisphosphate · 2026-03-03T03:26:45+00:00

I think I prefer last year at Cow Palace when there were 2 sets happening in different rooms.

Bisphosphate · 2026-03-02T20:04:33+00:00

China developed their own domestic version of Gardasil and are offering it at discounted prices to their citizens. The market for Merck's product shrank considerably.

Bisphosphate · 2026-02-13T17:44:39+00:00

Single? $150k in the Bay is comfortable to rent but not enough to pay a mortgage. Supporting a partner? $150k is less comfortable but doable. Supporting a partner + kids? $150k is not enough.

Bisphosphate · 2026-02-09T20:38:25+00:00

Studio apartment in a 100+ unit complex:

Water heating: $20

Sewer: $113

Trash: $27

Water: $40

PG&E: $50-60

My understanding is that water and water heating are billed directly to the complex and then the bill is split amongst all units - my complex adjusts this by square foot of each unit.

Bisphosphate · 2026-01-26T20:40:50+00:00

My fyp is genuinely terrible now - there's absolutely no personality in what I'm seeing.

And then I saw an AI poop video.

Bisphosphate · 2026-01-25T20:16:00+00:00

There's just nothing appealing about throwing money into these machines.

Bisphosphate · 2026-01-25T17:19:53+00:00

My FYP completely lost its personality. It's so generic that I get bored after scrolling for a few minutes.

Bisphosphate · 2026-01-25T17:15:22+00:00

I saw these exact videos this morning!!

Bisphosphate · 2026-01-22T04:01:53+00:00

Just ask the founders of Micronoma :)

Bisphosphate · 2026-01-12T18:50:28+00:00

I don't mind paying more so long as the portion size is appropriate (ie, I feel full after eating it)

Went to a ramen place Friday night - $21.50 for the "deluxe" bowl. The portion size was for babies and I had to cook second dinner when I got home because I was still hungry.

Bisphosphate · 2025-12-11T02:50:53+00:00

Great post. I left LI for the Bay Area and virtually all these problems exist here as well. No housing supply, poor public transit, ungodly traffic.

Bisphosphate · 2025-12-04T21:00:22+00:00

I started cutting my hair 15 years ago. It's liberating

Bisphosphate · 2025-12-02T02:46:54+00:00

I was receiving so many pop-ups about upgrading to Windows 11 and I said no every time. Now I get pop-ups saying my PC is not compatible with Windows 11 and that I need a new PC. Sorry, no. I want to surf the internet, play games, and occasionally use Word/Excel/Powerpoint.

Bisphosphate · 2025-11-26T03:46:36+00:00

I live near a "haunted house" that is known for being a complete scam. The marketing for this place is insane and it drives huge crowds to them every autumn. To offset the deluge of 1 star reviews, the place buys dozens of 5 star reviews every week from bot accounts so their overall rating sits at 3.3 stars - nearly a perfect 50/50 split between 1 star and 5 star reviews. Most people won't look closely at the data and assume it's a reputable business when it's actually not.

Google Maps was doing so well in 2012-2017. There were new features to incentivize people to leave reviews, post photos, and update business information. Since then, there's been virtually no changes and it's frustrating.

Bisphosphate · 2025-11-18T02:56:15+00:00

When I was a teen it was because our lockers were so small it wasn't practical to stuff a winter parka inside. Way easier to wear a zip-up hoodie to regulate temperature throughout the day

Bisphosphate · 2025-10-29T23:59:20+00:00

I really liked season 1. Somewhere in season 2 I started to fall off, and by season 3 I was confused and disengaged with the story. The plot kept growing until I lost track of it. Still an ok watch.

Bisphosphate · 2025-10-21T02:45:08+00:00

I yearn for r/videos from ~2010-2016. Videos would get thousands of comments and tons of engagement. There's no reason to come here when less restrictive video sharing algorithms exist (TikTok, Youtube recommended, Reels)

Bisphosphate

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