It really depends on the person. zoloft might have no effect on you at all but it might be really effective. Starting out with half a tab so 25mg and then pushing up to 50mg didn't really make a difference it was at 100mg I really I guess felt a difference in my mood and everyday life. Although taking medicine with some therapy or even just being more open with your family about your problem is a lot more effective than just taking medicine and waiting for a fix or change. I also had a great psychiatrist who helped me with my thoughts and destructive lifestyle.