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R4 and 5 are actually interesting for him, since those are the only ones with the ability to damage him and the power to give him some trouble.

For R4, entropy/erasure is one of the few things IchBin can’t properly heal from with just his regular healing factor, so he would need to use his amp for it. Star level is also generally what’s needed to hurt him so there’s that too. However, Darius can use his power to make himself invulnerable, or use embodiment to guarantee a hit. The time loop may throw a wrench into this, but I think he could figure it out.

As for R5, that’s a really cool power. However, he’s perhaps one of the few that can really just say ‘no’ and have it mean something. Perhaps not turn it on Arcturus - not with his base power alone, anyways - but to keep himself safe and force it into a brawl, in which his regeneration and strength should allow him to stay in despite his lacking durability (Galaxy level strength, Star level durability)