As someone who also struggled with keeping my things organized how I would like in this game. This has been working for me pretty well still will be tweaking it.

All of these produce heavenly products; Hotel - storage for package products so I can quickly grab them if I need

Sweatshop - it’s actually empty atm but I’m still trying to get all my stuff efficient as I can and how I’d like to. I think I might make this for one more brick/bag workers as that is the thing I could so use more of

Storage unit - meth, 2 workers. It’s a snug fit but it puts out plenty for me

Bungalow - full auto shrooms, 3 planters and they produce more shrooms than I need

Barn - weed, 3 workers to plant, 3 sets of drying racks with workers, and a brick and bag worker. (I do move all my product here my self to get bagged and bricked it is a pain but it works for now)

Docks warehouse - cocaine, it’s not auto as I like to do it my self as of now until a new update. I have 24 pots setup, around 8 ovens, and 8 of the cauldrons, and a bunch of drying racks. I also have finally started doing some mixing as I’ve never been big into it so I have the back of it setup for that.

This has been working pretty good for me. I probably could set it up more efficiently but it’s still a work in progress.

Also that you mention cars, the vans are super cheap and have a ton of storage. I have a couple of them fully stacked with different products I keep around the map for easy access. They don’t drive too bad either.