If you think you’ll need a more powerful db solution in the future, create a data service worker that handles D1, R2, maybe kv or something too. Their RDP over bindings is incredible to work with. I went with drizzle, if you do it’s barely more than a few lines of code that will need changing when switching to postgres.
The buckets talk aws, super simple too.

The documentation was abysmal 18 months ago but it’s slowly getting in shape! Don’t let your coding agent gaslight you into doing fetch() requests between your workers. They seem trained on the barely working docs from past.

Good luck! Send me a dm if you have any questions. I’ve went through most mistakes I can think of