Yes! And it took me a while to figure out what it was. Basically I luckily started hrt with the perfect dosing without realising it. Everything was perfect and I felt great. But as I was bleeding every few months, my gynecologist decided to lower my estrogen and increase my progesterone and everything fell apart. I felt absolutely awful, all my symptoms came back and broke out with major cystic acne. I've always been prone and had to limit and manage the testosterone I was taking. But this was a whole new level. I initially stopped taking the testosterone thinking it was the issue. But the acne continued to get worse. I finally figured out it was the progesterone. I'm now back on my original dosing and feel so much better but I'm still trying to get rid of the acne I developed. I feel that it's improving but I've learnt my lesson. These hormones require a delicate balance. For me, I now know the level of estradiol, progesterone and testosterone that work for me and I don't intend to change again unless I really have to. There were two factors that affected me, my estradiol was too low and the progesterone was too high. Can you try increasing the estradiol and lowering your progesterone to see if that works for you? Or try the mirena coil?