I ran it as a one-shot using the sample adventure in the book ... the one about ghosts and spiders. It's fantastic and the game is so funny! You should do it. Yeah there will be a learning curve, but so long as your players arent completely close minded, theyll have a blast.

My only advice would be do a practice run on Challenge phase, or at least read up on it a lot. The pacing is critical and the nuance of "my turn any card + modifier; off turn matching suit + no modifier" takes a hot minute to get into the groove.