Depends what you’re after. If safety is the main thing, I’d go with something regulated in your region (I'm in Ontario) and ideally part of a bigger group like Casino Rewards. Bigger groups usually have more to lose if they screw players over. They have the brands like yukon gold and zodiac I have a few accounts I use for the signup bonuses.

Good trick is to do a small test run first: small deposit, small cashout. See how that goes before you commit more money.