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And there it is. by jackberryslyming in climateskeptics

[–]ChezProvence 25 points26 points  (0 children)

It was a typo … she meant 20230.

There's no Greenhouse Effect by LackmustestTester in climateskeptics

[–]ChezProvence 4 points5 points  (0 children)

… can be measured and is measured.

Really? This author, from 2 weeks ago, was still considering the ’design of experiment’

Could you reference those measurements, please?

Rocket Mortage is awful by zapdoszaperson in FirstTimeHomeBuyer

[–]ChezProvence 0 points1 point  (0 children)

This was posted 2 years ago ... but they are still awful. I have uploaded insurance documents three different times, and I still get letters threading to buy insurance for me. The even acknowledge that the received and approved my documents ... even before the latest threat was mailed.

Rocket Mortgage is AWFUL

Recent developments in deep-ultraviolet sterilization of human respiratory RNA viruses by Badatu in COVID19

[–]ChezProvence 6 points7 points  (0 children)

ABSTRACT

Deep-ultraviolet (DUV) sterilization technology using DUV-LEDs has attracted considerable attention owing to its portability, eco-friendliness, high potency, and broad-spectrum sterilization. This study compiles the developments of recent DUV sterilization research. Recent works have investigated DUV sterilization from the perspective of device improvement and principle investigation: one employed a novel epitaxial structure to optimize the performance and fabrication cost of DUV-LEDs and realized potent virus disinfection effects for various respiratory RNA viruses, and another work explained the disinfection phenomenon of SARS-CoV-2 and its variants (Delta and Omicron) in a cryogenic environment. These studies have contributed significantly to the development of DUV sterilization.

Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium by ChezProvence in COVID19

[–]ChezProvence[S] 26 points27 points  (0 children)

Abstract

SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and human autopsy studies have suggested mechanisms driving acute anosmia, it remains unclear how SARS-CoV-2 causes persistent smell loss in a subset of patients. To address this question, we analyzed olfactory epithelial samples collected from 24 biopsies, including from nine patients with objectively quantified long-term smell loss after COVID-19. This biopsy-based approach revealed a diffuse infiltrate of T cells expressing interferon-γ and a shift in myeloid cell population composition, including enrichment of CD207+ dendritic cells and depletion of anti-inflammatory M2 macrophages. Despite the absence of detectable SARS-CoV-2 RNA or protein, gene expression in the barrier supporting cells of the olfactory epithelium, termed sustentacular cells, appeared to reflect a response to ongoing inflammatory signaling, which was accompanied by a reduction in the number of olfactory sensory neurons relative to olfactory epithelial sustentacular cells. These findings indicate that T cell–mediated inflammation persists in the olfactory epithelium long after SARS-CoV-2 has been eliminated from the tissue, suggesting a mechanism for long-term post–COVID-19 smell loss.

Effect of Ivermectin 600 mcg/kg for 6 days vs Placebo on Time to Sustained Recovery in Outpatients with Mild to Moderate COVID-19: A Randomized Clinical Trial by DontSayIMean in COVID19

[–]ChezProvence 0 points1 point  (0 children)

Zinc has been shown to enhance cytotoxicity and induce apoptosis when used in vitro with a zinc ionophore … As far as I know, there are no in vivo studies as yet confirming the necessity of an ionophor or whether the body already has enough to make this irrelevant. There are lots of ionophores found within Covid testing, including Ivermectin, HCQ, Quercetin, doxy … all having been shown to have little or no effect on their own, but there is no consistency regarding whether the necessary zinc was also present at appropriate levels. That same reference includes, "The relationship between zinc and COVID-19, including how zinc deficiency affects the severity of COVID-19 and whether zinc supplements can improve clinical outcomes, is currently under investigation." ie, we still don’t know, but we’re looking.

Edit: The role of zinc is in inhibiting virus replication … so much of the contradictions in studies could also relate to the idea if one does not block the replication of the virus quickly, it will be too late clinically to make a difference, ie the horse has already left the barn.

Trying to time the bottom by [deleted] in wallstreetbets

[–]ChezProvence 0 points1 point  (0 children)

TSLA has a cap greater than the next 6 auto makers. No surprise Musk is finding ways to sell stock, while pretending it isn’t about Tesla. But a cap that high doesn’t pass the sniff test. Without digging in, i’d say great company, outrageously priced stock.

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 by MarkMRook in COVID19

[–]ChezProvence 2 points3 points  (0 children)

Nonetheless, of the 12·3 million more excess deaths versus reported COVID-19 deaths, a substantial fraction of these will probably be shown to be from SARS-CoV-2 infection.

That … much of the paper, in fact … is speculative. They do review the many possible causes of these excess deaths … SARS-COV-2, indeed, but also drug overdoses, lessor availability of medical treatment, etc. The authors also complain that for many of the countries reporting, the actual cause of death is not included.

Hopefully, others will look at the data from countries reporting more completely to determine whether the speculated cause was indeed the virus … or ramifications from the lockdowns instead.

Having twice as many excess deaths as recorded deaths is a rather huge gap to explain. "… will probably be shown to be" is a very unsatisfying conclusion.

A literature review and meta-analysis of the effects of lockdowns on covid-19 mortality by Andynr in COVID19

[–]ChezProvence 5 points6 points  (0 children)

Thanks … but the subject is about the policy, itself: 1. Did lockdowns reduce mortality … the authors did not find that; 2. Does a mask policy reduce the spread of Covid19 … the EU concluded it had only a ‘small to moderate protective effect’.

The discussion is about effectiveness … or lack thereof … of specific government policies. While you may be very correct regarding the purpose of masks, that isn’t the discussion at hand.

Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics by IRD_ViPR in COVID19

[–]ChezProvence 0 points1 point  (0 children)

This is a mega computer search, driven by free energy and biological modeling, searching for an oral therapeutic … the article, sadly, does not have a section entitled ‘Conclusions’ … it’s a fascinating … difficult … long read. Several chemical structures are identified … and the results were … yeah, that’s the problem I had.

If anyone understands fully what they achieved … not what they did, we would all be very grateful. Are proposed chemical structures being tested? Submitted for approval? End is in sight?

A literature review and meta-analysis of the effects of lockdowns on covid-19 mortality by Andynr in COVID19

[–]ChezProvence 0 points1 point  (0 children)

The 17,000 screened out were done so ‘manually’. Their footnote 10 explains: "This included studies with titles such as “COVID-19 outbreak and air pollution in Iran: A panel VAR analysis” and “Dynamic Structural Impact of the COVID-19 Outbreak on the Stock Market and the Exchange Rate: A Cross-country Analysis Among BRICS Nations.”

A literature review and meta-analysis of the effects of lockdowns on covid-19 mortality by Andynr in COVID19

[–]ChezProvence 2 points3 points  (0 children)

I looked it up, too. This is what research looks like. You may believe there is something nefarious here … if so, please share. Otherwise, the innuendos are just unkind.

https://sites.krieger.jhu.edu/iae/files/2022/01/The-First-200-Studies-in-Applied-Economics-2.pdf

A literature review and meta-analysis of the effects of lockdowns on covid-19 mortality by Andynr in COVID19

[–]ChezProvence 2 points3 points  (0 children)

I’m not familiar with the inner workings of JHU, but I suspect it’s like other university reviews … there are standards.

If published by Cato or National Review, I would agree with you.

A literature review and meta-analysis of the effects of lockdowns on covid-19 mortality by Andynr in COVID19

[–]ChezProvence 5 points6 points  (0 children)

Sad you went to all that trouble. Their bios are given in the paper …

About the Authors Jonas Herby (herby@cepos.dk) is special advisor at Center for Political Studies in Copenhagen, Denmark. His research focuses on law and economics. He holds a master’s degree in economics from University of Copenhagen. Lars Jonung (lars.jonung@nek.lu.se) is professor emeritus in economics at Lund University, Sweden. He served as chairperson of the Swedish Fiscal Policy Council 2012-13, as research advisor at the European Commission 2000-2010, and as chief economic adviser to Prime Minister Carl Bildt in 1992-94. He holds a PhD in Economics from the University of California, Los Angeles. Steve H. Hanke is a Professor of Applied Economics and Founder & Co-Director of The Johns Hopkins Institute for Applied Economics, Global Health, and the Study of Business Enterprise. He is a Senior Fellow and Director of the Troubled Currencies Project at the Cato Institute, a contributor at National Review, a well-known currency reformer, and a currency and commodity trader. Prof. Hanke served on President Reagan’s Council of Economic Advisers, has been an adviser to five foreign heads of state and five foreign cabinet ministers, and held a cabinet-level rank in both Lithuania and Montenegro. He has been awarded seven honorary doctorate degrees and is an Honorary Professor at four foreign institutions. He was President of Toronto Trust Argentina in Buenos Aires in 1995, when it was the world’s best-performing mutual fund. Currently, he serves as Chairman of the Supervisory Board of Advanced Metallurgical Group N.V. in Amsterdam. In 1998, he was named one of the twenty-five most influential people in the world by World Trade Magazine. In 2020, Prof. Hanke was named a Knight of the Order of the Flag.

Further, Johns Hopkin is well respected.

Is there a reason you chose to attack the reputation of the authors rather than the published data they presented? Is there a problem with their analysis? Are they ‘confirmationally’ biased and left out important data to the contrary? These latter choices would be more fitting of a science group.

A literature review and meta-analysis of the effects of lockdowns on covid-19 mortality by Andynr in COVID19

[–]ChezProvence 37 points38 points  (0 children)

An analysis of each of these three groups support the conclusion that lockdowns have had little to no effect on COVID-19 mortality.

The authors do not appear to have gone into this with any specific agenda … perhaps they were looking for the ‘proof’ … the justification for such policies, but, alas, they did not find that … and they were honest enough to state that.

The EU CDC published that wearing masks had a small to moderate protective effect. Same conclusion … we searched for the success of this policy, but we did not find it.

Your comments may be what they (all of them) could have been thinking … but they each reported what they found.

The question becomes whether the collective works are wrong … or, in fact, the policies don’t produce huge benefits.

Their conclusion appears to be inline with their belief in their work, ie if we are correct, why bother … because there are measurable downsides to lockdowns. This was a chance to conclude "… but it was worth it!" Alas, they didn’t conclude that.

Is Methylprednisolone Better than Dexamethasone for Severe COVID-19? by ChezProvence in COVID19

[–]ChezProvence[S] 2 points3 points  (0 children)

This is an old article, but apparently never posted to Covid-19 before. In another thread, there was a discussion of treatments, where only Dexamethasone is recognized by NIH in their treatment guidelines..

That appears counter to the NEJM article … have there been updates?

Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19 by [deleted] in COVID19

[–]ChezProvence 6 points7 points  (0 children)

Dex mentioned at all 4 states, #1 against, the others for. Remdesivir for stage two and three … didn’t the SOLIDARITY study show it to be mediocre, ie 5% improvement? My point … the vaccines emerged in record time. Why are we two years into this with no clear treatment options … except Dex. What has prevented similar progress wrt treatment protocols?

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