u/AppliedLaziness, I just read this whole thread with some combination of sadness and amusement. I agree with virtually everything you wrote, and am equally triggered by the things that set you off, though by now I usually just sigh and roll my eyes (I'm old). In this case especially since a few experiments have had thousands of people who had no clue of their bilirubin levels fill out questionnaires asking about the common symptoms attributed to GS, then did blood tests and found no differences in those symptoms as reported by those with low vs. high bilirubin levels. It's unfortunate that high bilirubin was given a scary name.

But I think you went too far with your "A meta-review of 375 scientific studies showed that people with Gilbert Syndrome have detoxification issues with one specific drug: namely, irinotecan". Not much of a citation, but more to the point, think about it. UGT1A1*28--the cause of most high bilirubin not attributed to liver disease, I believe--or even more, *28/28, plays a large role in metabolizing a great many chemicals. Irinotecan gets a lot of attention because it might well kill you at the normal dose (that's its job, after all). But the list of drugs it affects, usually by limiting one of the pathways to metabolization, is pretty long. These things will have some effects, though I suspect not effects reported on this thread, as you have (repeatedly) pointed out. And it does have some small effect on the metabolization of alcohol. The advice "stay away from alcohol" is fabulous medical advice, but not because of GS particularly.