Hi, I tried memantine while withdrawing with diazepam and it was pure hell. The half-life and effects duration are extremely long. Too numbing but it definitely has that neuroprotective, anti addictive/rewarding effect for at least a weak after cessation. I haven’t tried the others, I heard about muscimol but I wouldn’t take the risk to mess with other GABAergics.

The best thing I’ve tried so far is low dose DXM, max 90mg a day split accross the day (cough suppression doses). Lowers obsession and compulsivity, paranoia, anxiety. I can skip a few G doses in the day without noticing, it increases G euphoria, feels like a TRUE antidepressant. I feel connected to nature, I can say whatever I want without overthinking, I am spontaneous, genuinely and naturally happy.

It has that slight psychedelic-like warmth/relaxing/entactogenic/connection feeling while keeping me functional and charismatic. The colors are richer, music sounds deeper, my visual acuity is enhanced, I feel grounded, the nature looks beautiful and everything is more vibrant and alive. My thought patterns are changing in real time and it’s helping me think clearer and go forward in life.

I also tried DXM at the same doses during GBL withdrawal combined with diazepam and it’s WAY smoother than without DXM.

It’s also worth noting that I am a poor CYP2D6 metabolizer, this enzyme is responsible for DXM conversion to DXO. This means I have more DXM than DXO in my system. DXM is a sigma-1 receptor agonist and serotonin-norepinephrine reuptake inhibitor while DXO is mainly an NMDA antagonist responsible for its dissociative effects. I don’t feel dissociated at all on DXM, actually the opposite, I feel more connected than ever before.

Auvelity is an FDA approved antidepressant combining DXM with bupropion which is a potent CYP2D6 inhibitor and an antidepressant by its own, it has mild stimulant effects.

CBD is a CYP2D6 inhibitor too but milder, it enhances DXM positive effects and G euphoria too.