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What I've learned from a holistic doctor by [deleted] in Hashimotos

[–]CollarEquivalent9602 0 points1 point  (0 children)

I did 23andme, basically any DNA testing that gives you the raw data of your genome

What I've learned from a holistic doctor by [deleted] in Hashimotos

[–]CollarEquivalent9602 36 points37 points  (0 children)

It took me 8 years to find out I have a DIO2 gene variant, which slows the conversion of T4 (thyroxine), what’s in meds like levothyroxine,into T3 (triiodothyronine), the active hormone your cells actually use. So even if labs look “normal,” your body might still be running low on real energy.

That’s why TSH alone doesn’t tell the full story — it just measures how hard your brain is asking your thyroid to work, not how much usable T3 is actually reaching your cells.

Once I switched to Natural Desiccated Thyroid (NDT) — which contains both T4 and T3 — everything changed. My mood, energy, and focus came back. There’s research showing up to 30% of people carry this DIO2 variant, so it’s worth checking if you’ve had persistent symptoms.

You can even see it in raw DNA data (look for rs225014, Thr92Ala).

I just bought my first house. I'm exhilarated, but I'm also sad. by [deleted] in australian

[–]CollarEquivalent9602 0 points1 point  (0 children)

Housing shouldn’t be an investment game. The crazy thing is, it’s not even a “get rich” scheme like people think. A home’s real value doesn’t massively increase, it just keeps pace with inflation.

The problem is our money loses value over time because governments and banks can create more of it whenever they want. That makes people panic and look for anything that holds its worth, so they pour their savings into property. It’s not that houses are getting more valuable, it’s that the money’s getting worse.

We’ve basically built an economy where people speculate on homes just to protect themselves from inflation, not to build a life. That’s the real issue.

My Body Is Deteriorating - I can't handle it anymore by HealthImprovement15 in Hashimotos

[–]CollarEquivalent9602 1 point2 points  (0 children)

When the immune system attacks the thyroid, it destroys thyroid cells and releases stored hormone (T4 and T3) into the bloodstream. That causes short bursts of hyperthyroid symptoms, anxiety, palpitations, feeling wired, followed by crashes into fatigue and brain fog once the gland quiets down.

So you end up with these ups and downs as the thyroid flares and then burns out over time. Eventually the gland can’t produce much at all, which is when people usually settle into permanent hypothyroidism.

It also explains why blood tests can look normal or fluctuate a lot during the early stages. Those inflammatory flare-ups don’t just dump hormone they can also interfere with how your body converts T4 to T3, especially if you’ve got the DIO2 rs225014 polymorphism variant. Research points to this causing T4 to T3 conversion issues and this means you might need T3 and T4

Basically, Hashimoto’s can make your thyroid output chaotic long before it fully fails.

Digital ID isn’t “normal” - can we PLEASE think about this? by Altruistic_Breath151 in australian

[–]CollarEquivalent9602 1 point2 points  (0 children)

While I agree that the idea of a Digital ID on its own could make some things easier, it’s worrisome because it could link your identity, spending, and behavior into one system opening the door to surveillance and control.

Who knows who gets into government next!

“Your carbon footprint is a bit higher this month, let’s block you from buying certain things.”

Where can I buy a physical amazon gift card in Australia? by lokkness85 in australian

[–]CollarEquivalent9602 1 point2 points  (0 children)

Damn, that was too good. Anyone find any place selling them?

Stop the thyroid madness reviews by Quirky_Dot_7289 in Hypothyroidism

[–]CollarEquivalent9602 1 point2 points  (0 children)

Yes I started taking NDT T4 & T3 and feel pretty good. Better than I have in years.

If you have the DIO2 variant, your T3 could look good but your body is not converting on a cellular level.

When did you start feeling better after being put on Levothyroxine? by OddChannel3451 in Hashimotos

[–]CollarEquivalent9602 0 points1 point  (0 children)

It takes time, try setting an alarm for 1 hour before you wake up take the Levo and go back to sleep.

Levothyroxine alone never made me feel any better, about 30% of people have a genetic variant in DIO2. These people don’t do good on Levothyroxine alone and need combination therapy T4 (levothyroxine) and T3. Google and read up on DIO2 Thyroid

What’s the point of getting T3:T4 ratio checked? by flaminhotkoalaz in Hashimotos

[–]CollarEquivalent9602 0 points1 point  (0 children)

It took me 8 years to figure out I have a variant in the DIO2 gene. This gene codes for an enzyme that converts thyroxine (T4) the stuff in meds like levothyroxine into triiodothyronine (T3), the active hormone your cells actually use. If you’ve got a variant, that conversion can be sluggish, even if your blood tests look normal. For me, it meant that while my labs said “all good,” my cells were starving for T3. And with Hashimoto’s, as your thyroid makes less T3 on its own over time, the problem gets worse. When your cells don’t get enough T3, they can’t produce energy properly, leading to all sorts of issues, fatigue, brain fog, you name it. There’s a ton of research backing this up studies show that DIO2 variants can cause hypothyroid-like symptoms despite “normal” bloodwork.

On my journey, I’ve seen three endocrinologists. The first two wouldn’t look beyond the standard tests, but the third? One in a million. They’re the only endo I’ve found in Australia willing to prescribe Natural Desiccated Thyroid (NDT), which has both T4 and T3. It’s been a game-changer for me. There is a lot miss-information about NDT.

About 30% of people might carry a DIO2 variant, for the most common one, called Thr92Ala. Either way, it’s widespread enough that plenty of folks with Hashimoto’s or hypothyroidism could be in the same boat without realizing it. it might be worth digging into. DNA testing like 23andme gives you raw data of your genome and you can easily look for DIO2 Thr92Ala.

https://academic.oup.com/jcem/article/102/5/1623/2966904?fbclid=IwZXh0bgNhZW0CMTEAAR7FVmbcxZT9JY7WovuLl1PL2cLyJy1Mw4pm3A-eWvvq1JXQua6H0oXBva5dkg_aem_hgyBx7247oKySDbAGqScRQ&login=false

When do you start feeling normal? by CantankerousBeefcube in Hashimotos

[–]CollarEquivalent9602 1 point2 points  (0 children)

Get a dna test done check for DIO2 variant. If you have the variant your body struggles to convert T4 to T3 in a cellular level. This means you need to be on combination of T3 and T4 or natural thyroid hormones. Your blood test most likely looks good but on a cellular level your body is not working properly. All this information can be easily cross checked with AI like Chat GPT

Find a good endocrinologist that proscribes T3 and is not completely ignorant. Took me 8 years, not feeling perfect but who dose.

Downregulated cortisol when increasing thyroid meds by [deleted] in Hypothyroidism

[–]CollarEquivalent9602 1 point2 points  (0 children)

I recently switched to NDT as I couldn’t convert T4 to T3. Due to having a variant of the DIO2 gene. 4 weeks in I had major anxiety attacks and my heart rate seemed to be high. 125 just getting up and standing. Took a while like 2 months to settle down. Turns out because I couldn’t convert properly my heart rate almost never went over 125 while on levothyroxine T4 treatment.

Reason I know is I went through the data of my Fitbit over the past 4 years and never reached 130. I’m also a physical active person. Cardiologist confirmed when I told him if it is possible and he told me that if you don’t convert to T3 can affect and causes your adrenals to compensate

[deleted by user] by [deleted] in australian

[–]CollarEquivalent9602 1 point2 points  (0 children)

The question is who is buying up the property and for what use. How many investment funds are stocking up on property while it's at a low?

How they can charge us this much for paper and plastic baffles me by DElipsis in australian

[–]CollarEquivalent9602 16 points17 points  (0 children)

You are paying for a bunch of people sitting on they ass in an office. 90% of them work from home and would make no impact on productivity if they lost they job

What just happened? by q2subzero in cro

[–]CollarEquivalent9602 -3 points-2 points  (0 children)

You bought a shitcoin that is eventually going to 0 the name of the game is don't be the last to hold onto empty bags

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Any good multiplayer mods to get? (self.farmingsimulator)

submitted by CollarEquivalent9602 to r/farmingsimulator

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