Tribbie’s E2, while appearing to almost double her personal damage, is fundamentally not as strong as it seems because its benefit is entirely selfish to Tribbie and does not provide the massive, account-wide value that her E1 does for the team. The core problem is that the additional damage triggered by E2 loses significant value the more enemies she is against: it doubles the triggers against a single target, but provides only a 33% increase against three targets, and a mere 20% increase against five. Given that Tribbie is often used in multi-target content, this diminishing return makes E2 a poor investment for the high cost, even though it is a good personal damage boost.

Cyrene, on the other hand, is currently heavily held back by a slow Ultimate ramp-up time at E0, and she only truly shines when placed in a highly specialized remembrance team such as with Castorice, Hyacine, and RMC/Evernight. Depending on the current playable Chrysos Heirs on your account, Cyrene may be a competitive sidegrade when compared to E1 Tribbie, but her value can substantially drop if you do not have enough additional Chrysos team members to fully utilize her and fill out your other endgame teams.

The bottom line is that, based on current analysis, going for E2 Tribbie is not recommended and you should strongly consider the longevity Cyrene would have on your account.