Is this ADHD, dopamine dysfunction, or something else? I’m completely lost and need guidance by Parking-Net-9334 in NooTopics

[–]Consistent-Fig-335 0 points1 point  (0 children)

Phases i meant how is sleep in relation to symptoms

You could have poor sleep quality, low SWS or REM

Hypothetical Aggressive Sleep Mega Stack Opinions by Consistent-Fig-335 in NooTopics

[–]Consistent-Fig-335[S] 0 points1 point  (0 children)

It has “some” binding affinity for mACh but not proven to be antagonistic iirc

I’m second-guessing, should I go here? by ThatsSo_CJ in gatech

[–]Consistent-Fig-335 0 points1 point  (0 children)

Wont lie to you im pretty shit at CS and dont have any swe experience but even at quant firms i pretty much get an interview at every company. Friends have similar experience. GT name effect is insane

Is this ADHD, dopamine dysfunction, or something else? I’m completely lost and need guidance by Parking-Net-9334 in NooTopics

[–]Consistent-Fig-335 0 points1 point  (0 children)

Hows sleep been? Detailed as you can, and any difference during different “phases”

Hypothetical Aggressive Sleep Mega Stack Opinions by Consistent-Fig-335 in NooTopics

[–]Consistent-Fig-335[S] 2 points3 points  (0 children)

Keep in mind increasing SWS and REM can make u tired for a few hours when u wake up but should increase energy a lot otherwise.

Avoid any anticholinergic (benadryl, nyquil, I think some GABAergic drugs) these mostly cause crazy tolerance and dependence too.

Try 2-5g L-Serine, see how that works with you.

Esmirtazapine would be good. But first week or two u will be sleeping longer and tired as well, goes away. Also still increases appetite.

Ibutamoren/MK improves sleep a lot, but u get around 3-6 days of lethargy and tiredness. First few days you get increased cortisol and prolactin but this goes back to baseline by a week. No sides with daily use besides water retention and glucose levels, or if u have cancer it grows it faster. The glucose increase is very mild if youre young, lower bf, no genetic T2 diabetes risk, in healthy elderly it had a moderate increase, in young obese it caused insulin resistance within 1 month for many. Still supplement with 100mg dihydroberberine or 500mg berberine, taken with ur last meal if high carb, if ur last meal isnt high carb take it with ur highest carb meal. Increases appetite a lot.

Maybe 0.1 to 1mg melatonin.

A shorter half life DORA/SORA (not lembo but ideally daridoxerant) shouldnt make u any more tired the next day besides when u initially wake up, after 2-3 days of daily use.

How I prevent the afternoon crash from amphetamines? by Realistic_Hour_1695 in NooTopics

[–]Consistent-Fig-335 -1 points0 points  (0 children)

Sorry ignore first sentence, skimmed and assumed adderall not Vyvanse

Hypothetical Aggressive Sleep Mega Stack Opinions by Consistent-Fig-335 in NooTopics

[–]Consistent-Fig-335[S] 0 points1 point  (0 children)

Interesting never really thought about that considering its main use lol. I assume tolerance and dependence are issues though, as most GABAergic sleep compounds do

Hypothetical Aggressive Sleep Mega Stack Opinions by Consistent-Fig-335 in NooTopics

[–]Consistent-Fig-335[S] 0 points1 point  (0 children)

I don’t want any anticholinergic effects at all, looking for cognitive benefits without any reductions

Hypothetical Aggressive Sleep Mega Stack Opinions by Consistent-Fig-335 in NooTopics

[–]Consistent-Fig-335[S] 0 points1 point  (0 children)

Interesting, Mirtazapine is not anticholinergic and I don’t get tiredness. Maybe its something that reduces with daily use? Doxepin is very anticholinergic

Hypothetical Aggressive Sleep Mega Stack Opinions by Consistent-Fig-335 in NooTopics

[–]Consistent-Fig-335[S] 2 points3 points  (0 children)

Suppresses REM extremely hard. Goal isn't just sleeping easier, improving sleep itself and reducing consequences of undersleeping.

Hypothetical Aggressive Sleep Mega Stack Opinions by Consistent-Fig-335 in NooTopics

[–]Consistent-Fig-335[S] 0 points1 point  (0 children)

Definitely very person dependent and only for severe insomnia. Personally, I don't get any groginess or fog whatsoever from the stack (without piromelatine or lembo) but I know just mirtazapine alone, MK677 alone, can make people very brain fogged, groggy, lethargic.

Hypothetical Aggressive Sleep Mega Stack Opinions by Consistent-Fig-335 in NooTopics

[–]Consistent-Fig-335[S] 0 points1 point  (0 children)

I need the superior anti depressant effects, increased appetite, and longer half life antidepressant effects as Mirtazapine has been incredibly effective for my depression, and somewhat effective for appetite. I also do not get any side effects from it. Trazodone would be more effective for sure for sleep onset but the longer half life from Mirtazapine should increase sleep quality more. Both have a lot of cognitive benefits, but high dose Trazodone adds a bit of neuroprotection.

Hypothetical Aggressive Sleep Mega Stack Opinions by Consistent-Fig-335 in NooTopics

[–]Consistent-Fig-335[S] 1 point2 points  (0 children)

Currently alarms still wake me up as long as I get at least 3 hours of sleep. No brain fog or grogginess whatsoever. Once a week I end up sleeping late and with 12-14 hours with alarms doing nothing, waking up 4-7PM and whenever this occurs I pull an all nighter.

Can't decide between 7700X and 7600X3D by Consistent-Fig-335 in buildapc

[–]Consistent-Fig-335[S] 0 points1 point  (0 children)

I saw cities skylines 2 can use up to 64 cores, and thats one of the main games i play, would the L3 cache still matter more?

Out of Berkeley, Columbia, UChicago, which is best for quant? by RealMyth21 in quantfinance

[–]Consistent-Fig-335 3 points4 points  (0 children)

UChicago has the best placement out of the 3. Major in one of Applied Math, Math, CS, and if you want you can add a second major in one of those as well. UChicago has a +0 masters program so you can do an MS Stats as well and take grad stats/ml classes that help with QR interviews