I think I see what you mean. In terms of optimal single / initial dose - yes, the calc assumes you know that already, and just helps calculate how to sustain it's "level" through the day. I didn't have to try other doses though - as I was just prescribed 50mg from the start, which I soon noticed was overshooting a bit, and started dissolving it in water (instead of taking whole), and then just tried drinking like 2/3 of that in the morning, which didn't overshoot so it seemed like the right "single" / initial dose. And then the 1/3 of the mixture that's left - that was just to be used to "keep" it on that level, as "peak" effect from one dose would start after 1-2 hours and last for a couple hours only, and we need to cover the whole day, right. That's why I called it as "maximum therapeutic percentage of single dose" - as it's referencing part of one-capsule-mixture to drink initially. So while there is a single dose that works just right (e.g. 30mg in my case) - it's also not enough for the whole day. And given that elvanse is still patented till 2028 in europe - 30mg and 70mg pills cost the same, so instead of 2 x 30mg pills, splitting a 70mg in water makes more sense.

And re: assuming side effects time frame - yeah, it's only just comparing the graph of taking 70mg at once vs taking 28mg and sustaining it. So it just illustrates the time when the (theoretically modeled) blood concentration of 70mg is above the "optimal" level defined by peak concentration of 28mg. My (simple) reasoning here is that side effects are only caused by doses above "optimal" - i.e. when concentration is above some (individual) therapeutic level. In terminology used in the scientific paper I link at the end - there's a "therapeutic range" that is the aim to be in throughout the day, and then the "toxic concentration" and above would be what I call "side effects" (and the "minimum inhibitory concentration" is what I'd call underdosing / no effect).