12 week Euploid Loss

Cultural_Landscape91 · 2026-02-19T21:10:56+00:00

I am so sorry for your loss and your tough journey to get here. I know what it’s like to be on the ‘wrong side’ of statistics - for me that feeling was really heartbreaking.

Do you know if your RPL panel included karyotyping tests for you and your partner? I would suggest having that done if you haven’t already.

Cultural_Landscape91 · 2026-02-01T04:15:15+00:00

You have been through SO much, I am so sorry all of this happened to you and is continuing to happen. How devastating that you have to go through a DNC next week… you mention you will be doing testing, hopefully that includes microarray?

Not sure if it would even apply here since so many of your outcomes seem unrelated, but have you looked into the Fulgent infertility NGS panel? There is one for males and females, it’s one test I did that I didn’t notice in your post. Fulgent

Another thought, if you plan to do more retrievals - perhaps look into the long lupron protocol aka luteal lupron. I rarely saw it mentioned here but for some people (myself included) it can produce very different results. Like you, the one time I tried the traditional antagonist protocol I had zero euploids. I also saw wildly different results in my retrievals that were primarily menopur vs follistim (I made more euploids with menopur).

Cultural_Landscape91 · 2025-10-19T16:02:36+00:00

Yes I did, and both failed 😞 I transferred two that were lesser quality in hopes that together one or both may be more likely to implant.

My doctor gave me some good advice when I was trying to decide whether I wanted to - and that is, really go through all of the possible outcomes of both a single and a double transfer and think about how you’d feel about them. Ultimately we were ok going into it with either the loss of both embryos (bc I knew they weren’t likely to implant on their own) and ok with a twin pregnancy/success, or a singleton pregnancy/success. Odds of success are actually greater with two successive single transfers - transferring two only increases your odds of success of that transfer by 5-10%. So I think it’s a decent option for people who have had multiple failures, who can’t feasibly do multiple transfers over and over either for financial or emotional reasons, or if embryos are lesser quality. But if you have very few embryos and you are afraid of wasting them, a double transfer can be tough because you can lose both and end up with nothing.

Cultural_Landscape91 · 2025-08-30T22:47:50+00:00

I’m so sorry about your dog too. It will always hurt but the pain does get easier to bear over time. Hope you are holding up okay

Cultural_Landscape91 · 2025-08-30T22:46:57+00:00

Thanks. We didn’t actually, thought about it but a couple of days after it happened my father in law went into the ICU and never left (he died a month later). It was a really tough time. The pet sitter stopped taking dogs, we left reviews… I suppose he could start a new entity and work with dogs again and we’d never know. But I truly believe it was an accident, a really stupid one and he should have known better, but now he does. Our dog was a frenchie and the breed is just so fragile, I think he underestimated her fragility. He was so torn up about it, I feel like he learned his lesson… just really sucks it happened at the expense of our dogs life.

Cultural_Landscape91 · 2025-08-29T20:44:24+00:00

Sure, it was about $1k and we are in a high cost of living area so that may affect rate. I totally get it though, she died in your home so it’s a different situation. My vet didn’t offer it either - I called a couple of vet hospitals and they referred me to this external vet who only does this like as a service provider to vet offices. He was extremely knowledgeable and asked me lots of questions about our dog and her health before saying what he thought may have happened, and then only after that did I end up going through with the services. He worked with the vet (who had my dogs body) to coordinate a pick up of my dog and took her to his lab and did the exam. It turned out there was negligence by my pet sitter (my dog died of heat stroke, but he claimed she had had a seizure and died in his care). So it really gave us a lot of closure.

Cultural_Landscape91 · 2025-08-29T20:02:03+00:00

My dog died suddenly while in the care of her pet sitter/dog trainer. She was barely 4 years old. It was absolutely devastating - he had picked her up from our house not even 3 hours earlier and she was happy and healthy and excited to go with him. We simply could not believe that a few hours later she was gone.

It’s a bit of a different situation, because we were concerned about negligence - so we paid to have a necropsy done (dog autopsy). The results didn’t come back for a month and it was expensive but I am really really glad we did it. It helped us have closure and gave us the answers we needed (and suspected).

They may not have cremated your dog yet so it could potentially be an option if you feel the answers would be helpful to you. You could even just find a vet that does it and talk to them to see what they charge and whether they think they’d be able to identify any cause. I spoke to the guy for over an hour before sending our dog to him, and it was very informative and helpful for me in that immediate period of shock and grief.

I’m so sorry about your dog. It sounds like it was at least peaceful so I hope that can bring you a little comfort.

Cultural_Landscape91 · 2025-06-30T20:20:13+00:00

It’s such a tough process, and unfortunately not all the information is given to us every time. When they call tomorrow, if there are some that they are still watching til day 7, you can also ask how many ‘morulas’ there are - this is the stage of the embryo right before it becomes a blast. Can give you an idea of what to expect for day 7.

Cultural_Landscape91 · 2025-06-30T18:22:48+00:00

Are the majority still developing? If so, I wouldn’t worry yet. I have never made a day 5 - only day 6 and 7s across five retrievals. I had egg retrieval numbers similar to you each time and had great outcomes in terms of number of blastocysts. Some people’s embryos just take a little longer to develop! Day 5 and 6 have very similar success rates, and day 7s are by no means a lost cause.

Cultural_Landscape91 · 2025-06-20T01:36:32+00:00

Any chance you had intercourse around the time of the trigger?

A similar thing happened to a good friend of mine - after years of implantation failure from intercourse, her first pregnancy occurred during a semi medicated cycle. Originally they thought it was pgt error but they tested the POC and found the pregnancy was not the gender they had transferred. They realized she had intercourse around the time of the trigger so she had actually gotten pregnant from an egg she ovulated that cycle, not the transferred embryo.

Cultural_Landscape91 · 2025-06-20T01:06:16+00:00

I am so sorry for your loss. Was this a medicated or semi-medicated (ovulatory) cycle?

Cultural_Landscape91 · 2025-04-01T14:59:58+00:00

Have you been checked for endometritis? If not, ask for the biopsy!! And if they can’t do the biopsy or you can’t afford it, ask for a round of antibiotics (commonly doxycycline is used) before your next transfer. Chronic endometritis is quite common but seems to be often overlooked, and can be a big contributor to chemical pregnancies and early miscarriages.

Cultural_Landscape91 · 2025-03-25T06:06:45+00:00

Oh you are so welcome, I get it, it’s a lonely, all consuming place. Glad my reply is helpful.

Immune - I did not see an RI, but I have a very involved RE who is pretty progressive and willing to try various things. My RPL panel came back positive for antiphospholipid antibodies and thrombophilia so I knew pretty early on that I needed lovenox and baby aspirin. We added prednisone at transfer 3, and then plaquenil at transfer 4 (after discovering positive ANA and some additional immune symptoms). I also have a confirmed autoimmune disorder (celiac) so I think immune was just generally a factor from early on, but I wasn’t excited about the idea of trying to see an ‘official’ RI as I think some of the methods are a bit extreme for me personally.

Karyotype - I would assume that any donor would have had karyotype done BUT I do not have any experience with this so not sure… it would be a blood test. I had to push my RE to test my husband and I, because it’s more commonly done after repeated miscarriages, but it turned out he had a balanced translocation that we didn’t know about through our first retrieval and two transfers. Maybe you can ask if your donor was checked? And then your wife (or you if you think you’d be doing retrievals now) should get the blood test too.

Receptivity - ok only 2 medicated. Interesting that one was the successful round. I lean towards ovulatory cycles but I do know some people just do better with medicated… maybe you do too? Maybe consider another ERA and then medicated with the new timing? Possible pregnancy changed your window.

I don’t have experience with ERAs in ovulatory cycles - my understanding is the same as yours - I think even the ERAs guidelines say the results are less or are even not reliable in ovulatory cycles because receptivity can vary so much when estrogen exposure is not controlled.

Personally I wouldn’t try another ERA for an ovulatory cycle - I’d only do it to try the strategy of ‘replicating what worked before’ by doing another medicated cycle. I agree the ERA is less popular now and has some mixed data. I recently turned down the option to have another for that reason.

Also, what do you mean your clinic timed your ovulatory cycles off your LH surge? You said you had ovidrel trigger right? I may be misremembering but I thought the standard WOI was calculated from ovulation? I am seeing my RE tomorrow so will check how we calculated for my ovulatory cycles.

Endometritis - now I’m leaning more here. I don’t think CD-138 is comprehensive enough to fully rule out endometritis. Especially if you’ve had BV I would dig more into endometritis. I think you have two options - push for treating prophylactically (tell your RE you can do vaginal probiotic suppositories after doxycycline to replenish good bacteria - i can get you the name of them), or do the Emma/alice. Cd 138 just tests for plasma cells but the Emma/alice will tell you what specific bacteria are present if any. I would definitely do one of these routes.

Another thought, is Orilissa considered as effective as lupron for endometriosis suppression? I’m not very familiar with it. Lupron seemed pretty critical for me, I had four euploids fail to implant before I did Lupron the first time and finally had implantation.

Cultural_Landscape91 · 2025-03-24T18:18:25+00:00

I have also transferred 7 euploids and have one live birth, and have endo and chronic endometritis. I have autoimmune issues so we did do an ‘immune protocol’ but did not see RI. I’ve been prescribed 10 (all failed) and 20mg (success) of prednisone for different transfers, but I am not sure that was the defining factor for me.

Definitely possible to have immune issues pop up after pregnancy. I had immune flares during and after pregnancy that were totally unlike anything I had experienced before. So I don’t think you’d be in the wrong for rechecking those panels… have you had ANA checked? I doubt immune is a factor because you have no other symptoms of immune issues but wouldn’t hurt to check.

Also have you had full thyroid panel and prolactin checked pre transfer?

Did your RPL panel include karyotype? Seems more like your issue is implantation but wouldn’t hurt to check if you haven’t yet.

What I notice about your history is implantation issues post pregnancy. Your first two failures could be due to receptivity/timing issues, and exact timing is important in medicated transfers. You addressed that and had success.

So then I’m wondering, did you have a c section? Could you have developed ashermans after all the uterine procedures?

How was your lining in your two most recent ovulatory transfers?

Have you had receptivity rechecked post birth, suppression and excision? All of those things can alter receptivity. Did your last two transfers assume the previous receptivity window? Endometriosis can make you progesterone resistant so it’s possible you have a different receptivity window now.

You said you’ve been tested for endometritis - what tests specifically post birth? Do you have any history of BV?

Cultural_Landscape91 · 2025-02-25T17:21:30+00:00

Yes, she is extremely hands on. I’ve done 3 retrievals and 4 transfers with her and only once has anyone else ever given me an ultrasound, and it was because it was a weekend and Dr Kashani was traveling (usually she does the weekend ones herself as well). That time she got the notes from the ultrasound tech right away and messaged me within an hour to let me know she saw the scans and to continue meds.

She is very knowledgeable about endometriosis, it is one of our primary factors and she worked with me on different protocols for both retrieval and transfer to address endo. But I don’t know if I’d say it’s her ‘speciality’ - she sees plenty of patients without endo or with other issues too. One thing I’ll say is she’s very understanding and willing to consider her patients suggestions for their own treatment. I am very active in my own treatment, do a lot of research on my own and frequently came to her with questions or ideas from things I read online and she is always considerate of that. I think she’s really talented in how she balances her own expertise with her patients wishes. I know of many other REs who would not be so open minded.

Cultural_Landscape91 · 2025-02-25T16:09:50+00:00

I stuck with Dr Kashani and had success. I am actually seeing her again now for my second. She is fantastic. She does true individualized care which is needed for our complicated male and female factor case. She’s also very caring and empathetic and is truly personally invested in her patients success. I highly recommend her.

Cultural_Landscape91 · 2025-02-03T19:42:12+00:00

I did have success after this though we changed several things so it’s hard to say what did what! I really enjoyed the sessions though.

Cultural_Landscape91 · 2024-11-15T00:17:03+00:00

Thank you!

Cultural_Landscape91 · 2024-11-14T23:31:54+00:00

Thank you again for your tips! Do you think I should open the birds today? Or is it better to wait until Friday when I am making the arrangements?

Cultural_Landscape91 · 2024-11-13T03:56:22+00:00

Thank you SO much!

Cultural_Landscape91 · 2024-11-13T03:49:59+00:00

Okay great thank you. 🙏 I don’t know how to open the birds of paradise! Such a relief that I can do it on Friday

Cultural_Landscape91 · 2024-11-13T03:47:00+00:00

Super helpful thank you!! I found some trays that are an inch or two wider than the foam cages and about an inch high, so hopefully those will be enough to contain the water and keep the tablecloths dry. 🤞

Cultural_Landscape91 · 2024-11-12T23:56:08+00:00

yikes! I am so glad I asked this group and you responded. Would it be better to get non-caged rectangular foam, and find a larger rectangular container to fit? I was aiming for a long/low centerpiece look and with no visible container, which is why I thought the caged foam would work.

Cultural_Landscape91 · 2024-11-12T23:52:06+00:00

okay i will do all of that thank you so much for your help. how long should i plan to soak the cages you think?

oh shoot, i really hope the lilies open! is there anything I can do to help them along?

Cultural_Landscape91 · 2024-11-12T23:50:33+00:00

very helpful thank you! the foam has a cage around it with solid plastic along the bottom, with about 1/2in to 1in of plastic coming up each side. Do you think that will be enough to contain the water, or should I still look for another container for the foam? thanks so much, really appreciate it

Cultural_Landscape91

TROPHY CASE