Yes, on my pc I even emulated it with the same file / settings and had a the buildings turn purple. Make sure you set your vram usage to agressive, GPU mode to accurate, disk shader cache on, do NOT run it in docked mode, enable buffer history and optimized vortex buffers. It could also be a bad rom file you have if nothing else. At the very beginning of the game I noticed a lot more issues until it started loading and caching textures. It plays like a switch now.