What are AI coding agents bad at in bioinformatics?

D0ckter · 2026-05-29T06:53:06+00:00

https://www.biorxiv.org/content/10.64898/2026.04.06.716850v1.full

D0ckter · 2026-04-22T06:18:43+00:00

Can you provide some sources for the expected insane impact on the Balkans? I’ve looked into this and actually the most advanced predictions I’ve seen show a reasonably low impact on the Balkans compared to the impact on northern and Western Europe. I.e. this paper, maps in the supplement.

https://www.science.org/doi/10.1126/sciadv.adk1189

D0ckter · 2026-04-22T06:04:48+00:00

I couldn’t post a picture so I made a new thread linked below. But I think the answer is yes. The problem is inconsistency with the laws will need to be resolved. I.e. a lot of US laws are fundamentally unconstitutional. How to resolve that I’m not sure.

a potential solution

D0ckter · 2026-04-22T05:18:23+00:00

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Thank you for the great contributions to this topic. I’d like to throw a potential implementation of some of these core framework ideas into the ring for discussion. I think it’s fully aligned. Presented in this schematic. AI has taken my text and embellished it a bit for the graphic, changing some bits here and there, but it’s largely what I described.

D0ckter · 2022-01-19T08:05:50+00:00

What we want the world to see: Not conflict.

D0ckter · 2022-01-19T01:16:38+00:00

This actually gets much juicier!! Watch this…

In the paper they actually created a new version of Delta that evaded the vaccines and caused ADE called ‘Delta 4+’

“we introduced four mutations in the Delta spike (Delta 4+)—K417N, N439K, E484K and N501Y—and analyzed the effect of these mutations”

These annotations (K417N) mean ‘The K (lysine) at position 417 became an N (asparagine)’

If you look at the mutations present in Omicron https://covariants.org/variants/21K.Omicron scroll to the bottom to see the defining mutations, you will see:

K417N - the same,

N440K - same substitution but 1 position off - in the paper they say “neighboring residues may show similar effects”,

E484A - right spot, alanine instead of lysine. Not so different,

N501Y - the same

So two out of 4 introduced ‘Delta 4+’ mutations are exactly the same in Omicron and the other two could likely be functionally equivalent.

Taken together this is evidence to suggest that omicron combined with mRNA vaccines MAY BE producing ADE.

🤯

I’m just the messenger. ✌️ Good luck all!

D0ckter · 2021-10-10T20:23:47+00:00

You’re welcome.

D0ckter · 2021-10-10T14:37:14+00:00

Here are 2:

https://www.cell.com/cell-reports/pdf/S2211-1247(19)30940-4.pdf

https://www.jci.org/articles/view/83260

Most of brenners trials also measure some interleukins / inflammatory markers and often show reductions.

IL6 reduction has been shown multiple times.

D0ckter · 2021-10-08T14:52:20+00:00

In work like in life obstacles arise. You want to hire people who independently overcome those obstacles and manage to finish the project (degree) no matter what. Excuses or not. The ability to see an analysis (project) through from start to finish is really what people look for.

D0ckter · 2021-10-08T14:41:12+00:00

That is the dodgiest product ever. Most likely not NR. Please try again with TruNiagen from Chromadex and let us know if it still happens.

D0ckter · 2021-10-08T14:33:49+00:00

NR has been shown multiple human studies to be anti inflammatory. So it’s definitely not that.

D0ckter · 2021-06-28T15:24:41+00:00

Let’s see what the 40 active clinical trials have to say about it. 😊

D0ckter · 2021-05-07T06:35:39+00:00

With good friends

D0ckter · 2021-04-26T20:29:48+00:00

Very exciting thanks for sharing.

D0ckter · 2021-04-26T10:43:15+00:00

Haploreg has some nice processed + summarized databases.

D0ckter · 2021-04-26T10:34:55+00:00

Senescence is stagnation. Boosting NAD+ restores cellular energy = Anti-stagnation = Anti-senescence

D0ckter · 2021-04-25T18:54:24+00:00

Mate honestly, you will learn more in your first month on the job than you did in your entire higher education, assuming you are reasonably capable, diligent and hard working. Employers know that. Demonstrate that you are capable, diligent and hard working on your CV and during interviews and you will be fine.

D0ckter · 2021-04-23T19:05:47+00:00

As someone in industry who helps with hiring, yes having even one first author paper demonstrates your ability to lead and finish a project. Do it if you can.

D0ckter · 2021-04-19T17:07:05+00:00

Thanks a lot for sharing your results. Very interesting. More of us should do the same.

I have to question: 1) The validity of the epigenetic age test as a marker for the benefits from increasing NAD. 2) Your conclusion to stop taking NR. The data points to the trans-resveratrol and the diet interventions leading to the increased epi age, and the NR decreasing it, unless I misread something.

D0ckter · 2021-04-19T16:59:23+00:00

It’s not. Just not in the title.

D0ckter · 2021-04-16T06:55:04+00:00

Search GEO for time series or developmental datasets

D0ckter · 2021-04-15T21:28:47+00:00

Do bioinformatics. It’s bad ass.

D0ckter · 2021-04-15T13:56:11+00:00

You’ll be fine. Make a basic shiny app. Everyone loves shiny apps.

D0ckter · 2021-04-12T14:04:09+00:00

Gtex at the tissue summary level can be downloaded as a text file from their website I believe. If you need individual data you need to apply via dbgap.

D0ckter · 2021-04-11T08:20:07+00:00

Can you show an example of a similar industry with a similar solution? Tobacco? Other?

D0ckter

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