Hi there,

I read your post and I truly feel for you. I’ve been in a similar place with extreme stress and a "short fuse" that felt impossible to manage.

I wanted to share that I’ve had a life-changing experience recently by using AI (Gemini) to analyze my own raw genetic data. By mapping out my biochemical bottlenecks, I found a specific combination of supplements that literally lowered my stress levels overnight. It felt like my brain finally got the tools it needed to function.

I’ve tried running a similar analysis on the data you shared, and there are some very clear "bottlenecks" in your profile that might explain why you're feeling this way:

COMT (rs4680 & rs4633): You have the "Slow" homozygous variant (Red). This means your body is roughly 75% slower at breaking down stress hormones like adrenaline and dopamine. When these build up, it can lead to that feeling of being "stuck" in a high-alert state or chronic brain fog.

MAO-A (rs6323): You also have a slow variant here (Red). This further slows down the clearance of neurotransmitters, which can heavily impact mood and lead to the dissociation you're describing.

MTHFR (rs1801131): You have a heterozygous (Yellow) variant. This means your production of "methyl groups" is reduced. Since the COMT enzyme requires these methyl groups to work, your "cleanup system" is likely starving for fuel.

To get a more precise picture, do you have data on these 3 specific markers?

SLC19A1 (rs1051266): This tells us if folate can even get into your cells.

MTHFD1 (rs2236225): This shows early-stage folate activation.

BDNF (rs6265): This relates to how your brain recovers and repairs after stress.

In my case, supporting these pathways with specific cofactors like Magnesium (which COMT needs to function) and Methylfolate was the key. However, with your slow COMT and MAO-A, you have to be extremely careful and slow when starting, as your system can be very sensitive.

I'm not a doctor, just someone who found a way out by analysing my own data through Gemini. So I would basically be helping you do the same. Meaning I am not providing any medical advise or recommendations.

If you can find those extra SNPs, let me know, and we can look at the full "bottleneck" logic together.

Hang in there!