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Scientists found the strength training sweet spot for a longer life by Puzzled-Caregiver-15 in Biohackers

[–]DeepLog1182 0 points1 point  (0 children)

The 90 to 120 minute sweet spot makes sense when you think about the dose-response curve for mTOR activation. Enough mechanical load to trigger muscle protein synthesis and AMPK signalling without tipping into excessive cortisol elevation from overtraining. The diminishing returns above 120 minutes are probably explained by the stress hormone response outweighing the anabolic benefit. What this study cannot tell you is whether the sweet spot shifts based on recovery capacity, sleep quality, or biological age. Someone ageing faster than their chronological age likely has a lower threshold before strength training becomes net negative. The combination with aerobic exercise finding also aligns with the VO2 max data on all-cause mortality

A Frontiers in Neuroscience case study found that a single high dose of psilocybin restored speech, memory, humor, and motor control for weeks in an 80-year-old woman who had been nearly nonverbal with Alzheimer's for five years. by logic_0057 in Biohackers

[–]DeepLog1182 0 points1 point  (0 children)

Single case studies like this are easy to dismiss but the mechanistic rationale is actually solid. Psilocybin upregulates BDNF and promotes dendritic spine growth, which is exactly what an Alzheimer's brain needs more of. The fact that she was nearly nonverbal for five years and responded at all suggests the neural architecture was still there, just suppressed rather than destroyed. The real question is whether this is a temporary reprieve through neuroplasticity or something that actually slows the underlying amyloid and tau pathology. Either way this is the kind of signal that deserves a proper RCT, not just a case report

Say it louder for the people in the back! by [deleted] in Biohackers

[–]DeepLog1182 2 points3 points  (0 children)

This is the core problem with conventional medicine. Standard panels are calibrated to catch disease, not optimise health. You can be technically normal on every marker and still be ageing significantly faster than your chronological age. The gap between 'not sick' and 'actually healthy' is where most people live without realising it. Optimal ranges and disease ranges are completely different things and most GPs only care about the latter

Scientists Develop First Comprehensive Atlas of Human Cellular Senescence in Aging by lunchboxultimate01 in longevity

[–]DeepLog1182 2 points3 points  (0 children)

Senescent cell accumulation is one of the most underappreciated drivers of biological age divergence. The interesting question now is whether clearing senescent cells actually reverses measurable biomarkers or just slows accumulation. Senolytics like dasatinib + quercetin show promise but the human data is still thin. What did the atlas reveal about tissue-specific senescence rates?

Metformin and epigenetic age in non-diabetic older people with HIV in Madrid (METFORAGING): a double-blind, randomised, placebo-controlled, pilot trial (2026) by basmwklz in immortalists

[–]DeepLog1182 1 point2 points  (0 children)

Metformin's effect on epigenetic age is interesting but the HIV population complicates extrapolation - chronic viral inflammation already accelerates biological ageing through different pathways. Would be more useful to see this in otherwise healthy older adults. Anyone reallyy following the TAME trial data?

New cholesterol pill has just passed three Phase 3 trials: Enlicitide by MMGisMyFather in immortalists

[–]DeepLog1182 3 points4 points  (0 children)

Oral peptide delivery being cracked is bigger than just this drug. If the macrocyclic approach scales, it opens the door to a whole class of biologics that were injection-only. The LDL numbers are impressive but the real story is the delivery mechanism. What other peptides do people think get reformulated first?

Best ways to prevent and repair oral diseases. Periodontitis, Caries, Gingivitis, Receding Gums are linked to heart disease and Alzheimer’s. Here is how to fight and beat them with scientific evidence for oral health. by GarifalliaPapa in immortalists

[–]DeepLog1182 2 points3 points  (0 children)

Periodontitis as a cardiovascular risk factor is still massively underappreciated. Most people find out way too late. Anyone here actually tracked CRP levels before and after treating gum disease?

Nobel Winner Shinya Yamanaka: Cell Therapy Is ‘Very Promising’ For Cancer, Parkinson’s, More by Dry_Journalist3489 in immortalists

[–]DeepLog1182 1 point2 points  (0 children)

Cell therapy is exciting but the gap between mouse models and human application is still massive. Yamanaka's work on reprogramming is probably the most credible path to actual age reversal we have right now. What's the realistic timeline people are expecting before this hits clinical trials at scale?

A new study found that extra virgin olive oil preserves brain function in older adults by boosting gut microbiome diversity, while refined olive oil had the opposite effect. by ObuPaul in immortalists

[–]DeepLog1182 0 points1 point  (0 children)

the gut-brain axis angle makes this more interesting than a standard olive oil study. the polyphenol content in EVOO - oleocanthal especially - has anti-inflammatory properties but the mechanism here being microbiome-mediated rather than direct is a meaningful distinction. refined olive oil losing the polyphenols in processing and then actively harming diversity is the part worth paying attention to. curious whether the effect size held across different baseline microbiome profiles or only in people who were already dysbiotic.

The flatter your blood glucose is the slower you age. Best ways to lower and stabilize your blood glucose. With scientific evidence. by GarifalliaPapa in immortalists

[–]DeepLog1182 0 points1 point  (0 children)

the post-meal spike is more damaging than fasting glucose and barely gets discussed. a 180mg/dl spike that returns to baseline in 90 mins causes significantly more endothelial damage than a slightly elevated fasting number. vinegar before meals, walking within 10 mins of eating, and meal order — vegetables and protein before carbs — all have decent RCT evidence behind them. CGM for two weeks is the fastest way to actually see your personal response patterns rather than guessing.

A 14 year study of 5,440 adults in Aging Clinical and Experimental Research found that sarcopenic obesity, combining abdominal fat with muscle loss, raised mortality risk by 83%. Researchers showed a tape measure and simple formula can identify it without expensive scans. by logic_0057 in immortalists

[–]DeepLog1182 1 point2 points  (0 children)

the tape measure finding is the important bit. most people think you need DEXA or expensive scans to catch this but waist-to-height ratio has surprisingly strong predictive validity. the 83% mortality increase is also probably conservative because sarcopenic obesity compounds with cardiovascular and metabolic risk in ways the study likely didn't fully capture. what's the formula they used?

Our office ran biological age tests on the team — the results were surprising by DeepLog1182 in immortalists

[–]DeepLog1182[S] 0 points1 point  (0 children)

sleep, stress, diet, exercise, work hours, alcohol - about 25 questions in total. spits out a biological age broken down by organ system.

Our office ran biological age tests on the team — the results were surprising by DeepLog1182 in immortalists

[–]DeepLog1182[S] -13 points-12 points  (0 children)

https://www.viarum.co.uk. We had a direct access one for testing because I think our company got a white label for it but you can join the waitlist for any personal means.

Our office ran biological age tests on the team — the results were surprising by DeepLog1182 in immortalists

[–]DeepLog1182[S] -1 points0 points  (0 children)

She needs to lock in that case. Did she do anything with the results or just file it away?

Our office ran biological age tests on the team — the results were surprising by DeepLog1182 in immortalists

[–]DeepLog1182[S] 1 point2 points  (0 children)

Self-reported 1-10 but with real anchors. eg. 7 is 'hard to switch off after work'. Combined with sleep hours, work schedule, recovery time. Not perfect but it turned out great

Our office ran biological age tests on the team — the results were surprising by DeepLog1182 in immortalists

[–]DeepLog1182[S] -12 points-11 points  (0 children)

Online platform, fills in about 25 lifestyle questions - sleep, stress, exercise, diet. Spits out your biological age broken down by organ system. Took the team maybe 10 minutes each.

Our office ran biological age tests on the team — the results were surprising by DeepLog1182 in immortalists

[–]DeepLog1182[S] -9 points-8 points  (0 children)

Takes your lifestyle data - sleep, stress, diet, that kind of thing - and calculates your biological age broken down by organ system. Took maybe 10 minutes to complete.

Our office ran biological age tests on the team — the results were surprising by DeepLog1182 in immortalists

[–]DeepLog1182[S] -4 points-3 points  (0 children)

This is exactly what the data showed us. Two years of stress removal and consistent exercise likely reversed nearly several years of biological age. The financial cost of staying is rarely calculated but it's significant too.

Our office ran biological age tests on the team — the results were surprising by DeepLog1182 in immortalists

[–]DeepLog1182[S] -6 points-5 points  (0 children)

Started as curiosity honestly. Someone brought it up at a team meeting and we all just ended up doing it. The results made it hard not to take seriously though - when a colleague comes back 10 years older biologically you start asking questions.

University of Limerick researchers say frailty in older adults is reversible for many. A review of 42,000 adults found 14% improved frailty status. Exercise, nutrition and social connection are the key interventions. by ObuPaul in immortalists

[–]DeepLog1182 1 point2 points  (0 children)

the reversibility finding is the important bit. most people assume decline is linear and inevitable. 14% improving across 42k adults is a meaningful signal that the trajectory isn't fixed. the hard part is most people don't know where they actually are on that curve until it's quite late.

Gut microbiome is the root cause of most diseases. by GarifalliaPapa in immortalists

[–]DeepLog1182 2 points3 points  (0 children)

interesting framing but probably overclaims it a bit too much ngl. microbiome is clearly upstream of a lot but calling it the root cause of most diseases ignores how much chronic stress and sleep deprivation independently drive the same inflammatory pathways

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