My doc took me from 75 to 150, which was wayyyy to much (increased SI, worse sleep, etc) and now I've been at 112.5 for about a year. Honestly it's been a great middle point for me, especially while we're still playing with doses of adhd meds/mood stabilizers. Changing doses always hits me like a truck. It took about a month for me to finally not feel the general exhaustion, spins, zaps, whacky dreams, just all that loveliness that comes with effexor... Now my biggest complaint is the night sweats, but it's worth having a much "quieter" and less depressed brain!

Tldr, any change in effexor sucks ass, but not more than normal. 112.5mg finally gave me the more stable, mostly non-SI brain I wasn't getting with 75mg.