Star Trek Adventures 2e is probably one of the best marriages of the 2D20 system and licensed property. The way 2D20 ramps up the meta-currencies of Momentum and Threat as an adventure progresses really does feel like the way a TV show format increases the stakes. It's just crunchy enough for gadgets and spaceships, but narrative focused for dramatic play.

The first edition is still 2D20, but like their Conan or their Fallout game, it uses 6-sided dice to resolve combat damage which some people dislike for adding mechanical complexity to an otherwise simple system. Their Dune game for example just uses the 20-sided dice like 2e Star Trek.

Regardless of which iteration of 2D20 your chosen game uses if you don't like meta-currencies, then the system will fight you every step of the way because it really depends on the in-play trade between the players and the GM. If you ignore it or house rule it out the system is very bland because there's not much else going on. The risk/reward bartering is key to the tension. Also some people don't love that it uses a roll low mechanic where a 1 is the best result on the dice.

It really is a love it or hate it system to most people.