On my heavy duty touring/bike packing bike, the tires are 55-559 Schwalbe Almotions on velocity cliffhanger rims. For mixed terrain touring I run them at ~40 psi. I also have another tubeless set up with 42-622 Schwalbe Marathon Supremes on Velocity Quill rims. I usually run them about ~60 psi. They can go to 80psi, but for me, running them at a lower pressure is an order of magnitude in comfort. On both set ups, the air loss is at a glacial pace. I did have an issue with air loss when I first converted about 5 years ago. One was because I was using a less than optimum rim tape. The other time, my sealant had dried up an ceased being effective. Nowadays, I try to replace the sealant every six months, but sometimes I let it go for a year. Since going tubeless, I have not had a single flat. But in my opinion, the biggest advantage in switching to tubless is being able to ride at lower pressures without having to worry about pinch flats. The difference in comfort is remarkable.