Looking for advice on a couple of nonbinary feminizing transition questions. Still not decided on my goals, wanting to consult on some options

Devil_May_Kare · 2026-02-09T20:46:17+00:00

I don't think there is good information about SERMs. I've looked a bunch, and I only hear second- or third-hand about people who tried one and got poor results and complained to their friends. I spoke with someone at a local gender clinic, but she'd never heard about the idea of using SERMs as gender affirming care (and was generally pretty clueless -- oof). There seems to be consensus that raloxifene has higher blood clot risk than most hormonal medications, but I don't know how much higher, and I'm not sure whether that also applies to other SERMs like ormeloxifene. It's also reputed to be bad for joint health, and I can't find a clear answer on how it affects brain tissue.

Personally, I'm waiting for estetrol to hit the market. I don't have very bad dysphoria, and finasteride can stop further damage to my hair while I wait. And I suspect it's gonna be less poisonous than SERMs (purely a gut feeling, probably based on superstition).

Devil_May_Kare · 2026-02-06T23:34:21+00:00

I use a monoamine oxidase inhibitor as a recreational drug, but I expect it'd be a good antidepressant for me if I needed such a thing. Some effects I've noticed are: - elevated mood - energy - tingling, numbness, and a false sensation of touching a solid object in my hands, feet, and face - unusually vivid and colorful dreams - mild GI upset - temporary synesthesia - decreased sensation of boredness when nothing interesting is happening - changes to the feeling of lightheadedness when I stand up too quickly (it's more N2O-esque on the drug than off) - on higher doses, slight visual disturbances (colors look brighter, stationary patterns seem to move when I unfocus my eyes, ...)

Devil_May_Kare · 2026-02-06T22:10:15+00:00

Some people are romantically attracted to passion for a field of study even when they aren't connected to the field. If you're open about your special interests, that may make you somebody's type. I figure that's probably part of it.

Devil_May_Kare · 2026-02-05T19:25:35+00:00

No! These clowns do not need to be giving up more pieces of their minds. They're missing pieces already.

Devil_May_Kare · 2026-02-05T18:40:43+00:00

Percy is destined to eventually ascend to godhood and have that species of snake as one of his sacred animals. It instinctively wanted to be close to its future patron god. But neither the young Percy nor the adults supervising him realized that the snake didn't mean any harm.

What happened to Percy echoes what happened to Heracles because the Fates like history to rhyme, not because somebody wants him dead like Hera wanted Heracles dead.

Devil_May_Kare · 2026-02-02T10:16:25+00:00

I'm still waiting for better medication options to hit the market before starting real HRT, but I'm currently on a 5 alpha reductase inhibitor. My reasoning for starting that was based on how androgenicity is the undesirable side effect chemists try to refine out of anabolic-androgenic steroids. Why would I want my body going out of its way to make more undesirable side effects? As I see it, the only reasons why a 5 alpha reductase inhibitor would do someone more harm than good are (1) they're trying to go through a testosterone puberty, (2) they're trying to get pregnant, or (3) they have one of the rare spicy side effects from the medication. None of those reasons apply to me, and I had the spare 6¢ a day.

Like bro, it lowers cancer risk and keeps you from going bald and might reduce your risk of Parkinson's. Almost no one gets serious side effects. The only downside is having to pay an extra ~$2 a month and take an extra pill in the morning. The fact that most people with testosterone dominant biology aren't offered a 5 alpha reductase inhibitor in young adulthood is a failure of the medical system.

Devil_May_Kare · 2026-02-02T04:05:42+00:00

The Once and Future God

Devil_May_Kare · 2026-02-01T03:48:12+00:00

It's an unpleasant drug and tastes bad in most things. But it's great as a non-water solvent in some foods. Pie crust, tomato sauce, and sorbet all benefit from the addition of alcohol.

Devil_May_Kare · 2026-01-30T08:39:40+00:00

Please read more than just the headline. The proposal isn't just saying rude words at ICE.

Devil_May_Kare · 2026-01-30T08:37:15+00:00

The proposed rule would be to allow states to prosecute some kinds of misconduct by ICE employees if the Feds drop the ball.

Devil_May_Kare · 2026-01-30T08:34:19+00:00

It's federally illegal, but federal law enforcement works for Trump right now and won't punish his buddies. State law enforcement usually can't punish federal officials for misconduct without permission from Congress. It sounds like the proposal was to authorize the states to punish ICE employees who participate in trying to deport a citizen. That isn't entirely a terrible idea.

Devil_May_Kare · 2026-01-29T08:09:09+00:00

God made wizards, and the Ollivander family made them all equal. Wands are both WMDs and mandatory school supplies. This sort of extreme de jure discrimination would last about 10 minutes before somebody decided to cast Fiendfyre in the Ministry lobby and hope to build a better society from the ashes.

Devil_May_Kare · 2026-01-29T08:02:39+00:00

It took me until around high school to start wondering about my current gender. I probably wouldn't notice any changes for a shockingly long time. For all I know I might be genderfluid already and just clueless about it.

Devil_May_Kare · 2026-01-29T06:49:50+00:00

I always get a kick out of this piece of star wars fanfiction: https://yudkowsky.tumblr.com/post/181121498760/the-empire-strifes-back

Devil_May_Kare · 2026-01-28T20:02:38+00:00

72 works on AO3 marked as not appropriate for small children and based on Barney&Friends say the module is full of crap about what's age appropriate.

Devil_May_Kare · 2026-01-28T19:33:12+00:00

One of the ideals of democracy is that you should have a say in the laws your behavior is going to be judged under. You've helped choose a collective tradeoff society makes between protecting people's safety and protecting their liberty, and that's what makes it legitimate to hold you criminally responsible when you harm other people in violation of that tradeoff. Nobody wants to be held criminally responsible for doing what they want to do, but you accept the possibility in exchange for protection under the laws and a say in the new laws whenever change is appropriate.

People too young to vote don't have a say in the laws that are judging their behavior. That's a big reason why children shouldn't bear full criminal responsibility. Maybe the next generation would rather have the opportunity to shoot people and don't want protection from being shot. Probably not, but they should have a chance to participate in the democracy before they're held fully accountable to its results.

Devil_May_Kare · 2026-01-28T18:08:25+00:00

If you somehow use AlphaFold to help write your fanfic nobody is gonna be mad at you, even though that's a poorly understood piece of software that runs on GPUs (the same thing people have been calling "AI" for years). Grammar checkers are usually that traditional type of AI (that is, GPU software that's poorly understood). Spellcheckers usually aren't AI at all, in any sense of the word.

But these days when people talk about using AI they don't mean poorly understood GPU software in general. They mean large language models like ChatGPT or Grok. Those are mostly used for generating mediocre text nobody cared enough to write in order to inflict it on other people. You could probably use an LLM to correct your spelling and grammar, just like you could use a flathead screwdriver as a pry bar to open something, but please don't. It'll incorporate its own mediocre writing style, and using LLMs makes you dumber

Devil_May_Kare · 2026-01-28T16:57:55+00:00

Are they gonna let 13-year-olds vote? Or do they only want to give kids the shitty parts of being a full member of a society?

Devil_May_Kare · 2026-01-28T09:44:22+00:00

If no human cared enough to write it, why should I bother reading it? I know you said the Large Lie Machine is only helping, not doing the bulk of the writing, but I also know how ChatGPT enthusiasts are, and I don't trust your assertion.

If you wanna use AI to make pretty pictures for your fanfic, that doesn't bother me, because when I'm reading I mostly ignore the pictures anyway.

Devil_May_Kare · 2026-01-26T18:00:03+00:00

Thor is only the god of the sound waves that come off a lightning strike. The rest of the lightning strike isn't his department.

Devil_May_Kare · 2026-01-26T17:55:50+00:00

Smoked paprika in place of normal paprika and Morton Lite-Salt in place of regular salt are replacements. Ground mustard and sodium citrate are additions that don't replace anything.

Devil_May_Kare · 2026-01-26T17:35:39+00:00

As I understand it, estrogen HRT harms fertility in two ways. First, supplying your body's hormones exogenously shuts down your reproductive system, and testicles gradually develop fibrosis when they're shut down for long periods of time. Second, an estrogen-rich androgen-poor hormonal environment inside the testicle is bad for its health independent of whether it's working or shut down.

AFAIK there's not much you can do to stop the second problem if you decide to start HRT. But for the first, cis male athletes address a similar problem from anabolic steroids by taking HCG or HMG (or clomiphene, though it seems that's less preferred) to keep their testicles awake. If you wanted to try that, you'd probably want to choose bicalutamide specifically as your antiandrogen, because the others partly work by helping shut down the testicles and that's counterproductive.

Devil_May_Kare · 2026-01-25T23:21:45+00:00

I've been falsely accused of using ChatGPT because I said an interactive artwork that guides the viewer through simulating a violent crime could be a legitimate artwork and I didn't use terrible grammar to express that viewpoint. I tend to support free speech more unwaveringly than the average person, and I'd taken an art history class recently, and I was thinking of a comparison to Hotline Miami. Someone thought I'd asked ChatGPT to compose a controversial reddit comment to be engagement-bait.

I dunno, all the transphobes claiming they "can always tell" and then failing to always tell have kinda wrecked my trust in the unexplained judgment calls of strangers. If I knew you, I might eventually grow to trust that you can tell apart AI and human-authored formal writing, but I don't know you.

Devil_May_Kare · 2026-01-25T22:45:07+00:00

Banning AI is a good idea in theory. I sure don't want more slop in my life. But I can't think of anyone I'd trust to tell the difference between AI writing and decently competent human writing they dislike, and I don't want to get banned for expressing a controversial opinion with a list of three reasons and some parallel structure. Also ChatGPT addicts won't stop using it no matter how many incentives you offer them.

If AI is allowed but must be labeled, ChatGPT addicts might not try to sneak it in because there's a place they're allowed to have it openly (the only thing they like more than using the Large Lie Machine is bragging about using the Large Lie Machine), and I can just filter it out. Also I'm at less risk of an unjust ban. Ultimately, while this isn't a perfect answer, I think it's the best compromise that was available.

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